Preprint
Unveiling neuronal microstructure in the human brain in vivo with time-dependent radial diffusivity in MRI
arXiv (Cornell University)
arXiv
07/28/2026
DOI: 10.48550/arxiv.2607.25749
Abstract
Diffusion time-dependence, defined as variations in diffusivity and/or diffusional kurtosis with diffusion time, has emerged as a valuable non-invasive imaging marker for characterizing tissue microstructural features, such as cell size, density, packing disorder, and membrane permeability. In white matter, diffusion time-dependent changes between the short diffusion time and long diffusion time in radial diffusivity (RD), defined as the diffusivity perpendicular to fiber tracts, were demonstrated to correlate strongly with mean axon diameter in ex vivo spinal cord tissues, and to reveal demyelination in mouse corpus callosum. Despite their potential to non-invasively unveil neuronal microstructures to improve the assessment and targeted therapy of neurological diseases, these novel image contrasts obtained at short diffusion times using oscillating gradient spin echo (OGSE) have only recently become feasible for human in vivo studies with high-performance gradient MRI systems. In this preliminary study, we characterized time-dependent RD with OGSE encoding in the human brain in vivo. The change in radial diffusivity between short diffusion time and long diffusion time (delta_(R)D) consistently exhibited high values in the corticospinal tract, indicating high sensitivity of delta_(R)D to large axon diameter in human brains. Imaging at a high OGSE frequency of 100 Hz and a moderate b-value of 800 s/mm2 produced the highest delta_(R)D in the corticospinal tract. This study established a baseline for future investigations of neuronal microstructural alterations in neurological disorders and diseases.
Details
- Title: Subtitle
- Unveiling neuronal microstructure in the human brain in vivo with time-dependent radial diffusivity in MRI
- Creators
- Ante ZhuJerome J MallerH. Douglas MorrisJeffrey P GuenetteFlavio Dell' AcquaChu-Yu LeeJeffrey McGovernStephan E MaierRaymond Y HuangAndrew L AlexanderMaureen N HoodDesmond Teck Beng YeoSteven CR WilliamsCarl-Fredrik WestinVincent B HoVincent A MagnottaHua Li
- Resource Type
- Preprint
- Publication Details
- arXiv (Cornell University)
- DOI
- 10.48550/arxiv.2607.25749
- ISSN
- 2331-8422
- Publisher
- arXiv
- Language
- English
- Date posted
- 07/28/2026
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9985214113102771
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