Report
Effects of Weightlessness on Vestibular Development: Summary of Research on NIH.R1
Creighton University
06/01/1998
Abstract
In our original application we proposed to investigate the effects of gravity on the formation of connections between the gravity receptors of the ear and the brain in rat pups raised in space beginning at an age before these connections are made until near the time of birth, when they are to some extent functional. We used the neuronal tracer, Dil, which could be applied to tissue obtained immediately after landing of the space shuttle, thus minimizing changes due to the earth's gravity. We hoped to determine whether the vestibular system develops in two phases, as do other sensory systems (such as the visual system). In these other systems the first phase of development is controlled genetically and the second phase is controlled by environmental stimulation. Our data collected strongly supports the idea that the vestibular system has these same two phases of development. The tissue obtained from the NIH.R1 experiment was of exceptionally high quality for our analysis. Therefore, we expanded our investigation into the ultrastructural effects of microgravity on vestibular development. For the sake of clarity we will subdivide our summary into two categories: (1) analysis of the branching pattern of axons between the vestibular nerve and the gravistatic receptors of the ear in flight and control animals, and (2) analysis of the branching pattern of axons between the vestibular nerve and the brain in flight and control animals.
Details
- Title: Subtitle
- Effects of Weightlessness on Vestibular Development: Summary of Research on NIH.R1
- Creators
- Bernd FritzschL. L Bruce
- Resource Type
- Report
- Publisher
- Creighton University
- Number of pages
- 4 pages
- Copyright
- Work of the US Gov. Public Use Permitted.
- Grant note
- CONTRACT_GRANT: NCC2-861
- Language
- English
- Date published
- 06/01/1998
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984071782202771
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