Biography and Expertise
Our current research focus is on the function and pharmacology voltage-gated sodium channels that drive the rapid upstroke of the action-potential throughout the body.
In the lab, we work at the interface of membrane biophysics and chemical biology. Our particular expertise is in the synthesis and expression channels harboring tailor made non-natural amino acids and the general application of chemical biological approaches to the study of voltage-gated channels. We have had success in expressing synthetic amino acids in many channel and receptor types for pharmacological studies of ligand and drug interactions as well as structure function relationships.
Subject areas:
- Signal Transduction
- Cell and Molecular Biology
- Biophysics
- Structure and Function of Membrane Ion Channels and Transporters
- Neurobiology
Research: Function and pharmacology voltage-gated sodium channels that drive rapid upstroke of the action-potential throughout the body
Current Project: Sodium channels as regulators of electrical signaling in the cardiovascular and nervous systems.