Abstract
MM-593 Sociodemographic Trends in Multiple Myeloma-Related Mortality From 1999 to 2020 and Effect of the COVID-19 Pandemic
Clinical lymphoma, myeloma and leukemia, Vol.24(Supplement 1), pp.S574-S574
09/2024
DOI: 10.1016/S2152-2650(24)01711-7
Abstract
Newer treatment modalities have improved survival in multiple myeloma over time, while it continues to be an incurable disease. We aim to study the sociodemographic differences and trends in multiple myeloma-related mortality in the United States in the last 2 decades and the effect of the COVID-19 pandemic.
We examined death certificate data from the CDC WONDER (Centers for Disease Control and Prevention Wide-Range Online Data for Epidemiologic Research) from 1999 to 2020 for multiple myeloma-related deaths (ICD-10 code C90.0) in adults aged ≥25 years. We stratified the data for sex, census region, urbanization, and place of death.
Between 1999 and 2020, 294,263 multiple myeloma-related deaths were reported in the United States in adults aged ≥25 years. The overall age-adjusted mortality (AAMR) declined from 7 in 1999 to 5.7 in 2019, with a small increase to 5.9 in 2020. Men had consistently higher AAMR compared with women. AAMR decreased over time in both groups until 2019, with an increase noted in 2020 (AAMR 1999: 5.8 women vs 8.7 in men; 2020: 4.6 in women and 7.6 in men) (average annual percent change [AAPC]: women –1.33 [95% CI, –1.4 to –1.17] vs men –0.82 [95% CI, –1.05 to –0.60]). When stratifying by census regions, the highest overall mortality was reported in the Midwest (MW) and the lowest in the Northeast (NE) (AAMR 2020: MW 6.3 vs NE 5.3; AAPC: MW –0.85 [95% CI, –1.1 to –0.60] vs NE –1.09 [95% CI, –1.36 to –0.85]). Metropolitan and nonmetropolitan areas had similar AAMRs during the study period. Looking at the place of death, inpatient deaths decreased over time (50.15% in 1999 to 29.69% in 2020) and deaths at home increased with time (26.46% in 1999 to 43.34% in 2020). Deaths at a hospice facility increased from 2003 to 2019, with a decline in 2020.
AAMR of multiple myeloma-related deaths has decreased in the last 2 decades in both men and women. Differences were noted in census regions, but not in urbanization level. More deaths occurred at home or hospice facilities over time.
Details
- Title: Subtitle
- MM-593 Sociodemographic Trends in Multiple Myeloma-Related Mortality From 1999 to 2020 and Effect of the COVID-19 Pandemic
- Creators
- Parisa Aijaz - Charleston Area Medical CenterHira Shaikh - University of IowaAmir Kamran - Charleston Area Medical Center
- Resource Type
- Abstract
- Publication Details
- Clinical lymphoma, myeloma and leukemia, Vol.24(Supplement 1), pp.S574-S574
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S2152-2650(24)01711-7
- ISSN
- 2152-2650
- Language
- English
- Date published
- 09/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984699520502771
Metrics
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