Abstract
MM-596 Underlying Cause of Death in Patients With Multiple Myeloma: A 21-Year Mortality Analysis
Clinical lymphoma, myeloma and leukemia, Vol.24(Supplement 1), pp.S574-S575
09/2024
DOI: 10.1016/S2152-2650(24)01712-9
Abstract
Multiple myeloma (MM) is a plasma cell malignancy that affects older adults. Complications of MM and its therapy, including infections, renal disease, and anemia, are well known. However, there are limited data regarding conditions that directly cause myeloma-related deaths.
To study the underlying causes of death in patients with MM.
We performed a retrospective observational study using the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) multiple cause of death data set. Our inclusion criteria were patients aged ≥45 years who had MM reported as a contributing cause of death from 1999 to 2020. Revised ICD-10 code C90.0 was used for patients with MM. We then stratified the data based on underlying causes of death (UCD). Age-adjusted mortality rates (AAMR) per 100,000 persons were obtained for each UCD.
A total of 291,314 (54.3% male and 45.7% female) MM-related deaths were reported in the United States from 1999 to 2020 in patients aged ≥45 years. In 84.17% of the patients, MM was listed as the UCD. The second most common UCD was identified as cardiovascular diseases (4.95%; AAMR 0.6), followed by other malignant neoplasms (3.36%) (12.7% of which were malignancies of the digestive system, 10.86% were leukemias, and 5.3% were lymphomas), and chronic lower respiratory diseases (0.72%; AAMR 0.1). Renal diseases including nephritis, nephrotic syndrome, and nephrosis were the fifth most common UCD (0.67%; AAMR 0.1) and cerebrovascular disease was the sixth most common UCD (0.58%; AAMR 0.1). Respiratory infections including influenza and pneumonia were the 10th most common UCD (0.27%). Even though the data for COVID-19 were from a single year (ie, 2020), it was the 11th most common UCD (0.25%) in MM-related deaths.
While significant therapeutic advances have been made in MM, disease progression continues to be the primary cause of death, as indicated in this analysis. Further treatment advancements and studies are needed to effectively manage the disease progression in MM.
Details
- Title: Subtitle
- MM-596 Underlying Cause of Death in Patients With Multiple Myeloma: A 21-Year Mortality Analysis
- Creators
- Parisa Aijaz - Charleston Area Medical CenterHira Shaikh - University of IowaAmir Kamran - Charleston Area Medical Center
- Resource Type
- Abstract
- Publication Details
- Clinical lymphoma, myeloma and leukemia, Vol.24(Supplement 1), pp.S574-S575
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S2152-2650(24)01712-9
- ISSN
- 2152-2650
- Language
- English
- Date published
- 09/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984699049202771
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