Book chapter
Effects of endothelin on cultured human and rat glomerular mesangial cells
Cellular and molecular biology of the kidney : International Symposium on Cell Biology of Nephron Heterogeneity--Fine Structure and Functions, Shizuoka, July 22-25, 1990 , pp.1-11
Contributions to Nephrology, v. 95, Karger
1991
DOI: 10.1159/000420633
PMID: 1666987
Abstract
Figure 5 summarizes our results and the data in the literature with regard to both short-term signalling and long-term signalling induced by endothelin. Short-term signalling, which induces vasoconstriction, is undoubtedly mediated by multiple signals including increments of cytosolic calcium, stimulation of protein kinase C and alkalinization of the cytosol. Endothelin also activates negative feedback pathways including arachidonate release with the synthesis of vasorelaxant prostaglandins and potentiation, in a prostaglandin-dependent manner, of beta-adrenergic-stimulated adenylate cyclase. Long-term signalling is less well understood and may depend not only on phospholipase activation with subsequent changes of calcium and protein kinase C but also stimulation of other protein kinases which phosphorylate key intermediates. Endothelin stimulates the transient appearance of protooncogenes that might play a role in the induction of cellular proliferation.
Details
- Title: Subtitle
- Effects of endothelin on cultured human and rat glomerular mesangial cells
- Creators
- Michael Simonson - Case Western Reserve UniversityTomohiro OsanaiShianq WannElisabetta BaldiPaolo MenéYuichi NakazatoMark Kester - Case Western Reserve UniversityChristie ThomasMichael Dunn - Case Western Reserve University
- Resource Type
- Book chapter
- Publication Details
- Cellular and molecular biology of the kidney : International Symposium on Cell Biology of Nephron Heterogeneity--Fine Structure and Functions, Shizuoka, July 22-25, 1990 , pp.1-11
- Publisher
- Karger
- Series
- Contributions to Nephrology; v. 95
- DOI
- 10.1159/000420633
- PMID
- 1666987
- ISSN
- 0302-5144
- eISSN
- 1662-2782
- Grant note
- DK-41684 / NIDDK NIH HHS HL-37117 / NHLBI NIH HHS HL-22563 / NHLBI NIH HHS
- Language
- English
- Date published
- 1991
- Academic Unit
- Stead Family Department of Pediatrics; Obstetrics and Gynecology; Nephrology; Internal Medicine
- Record Identifier
- 9984359911702771
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