Conference proceeding
Optical microsensor for continuous glucose measurements in interstitial fluid
Proceedings of SPIE, Vol.6094(1), pp.609403-6094010
Optical Diagnostics and Sensing VI
02/09/2006
DOI: 10.1117/12.646751
Abstract
Tight control of blood glucose levels has been shown to dramatically reduce the long-term complications of diabetes. Current invasive technology for monitoring glucose levels is effective but underutilized by people with diabetes because of the pain of repeated finger-sticks, the inconvenience of handling samples of blood, and the cost of reagent strips. A continuous glucose sensor coupled with an insulin delivery system could provide closed-loop glucose control without the need for discrete sampling or user intervention. We describe an optical glucose microsensor based on absorption spectroscopy in interstitial fluid that can potentially be implanted to provide continuous glucose readings. Light from a GaInAsSb LED in the 2.2-2.4 m wavelength range is passed through a sample of interstitial fluid and a linear variable filter before being detected by an uncooled, 32-element GaInAsSb detector array. Spectral resolution is provided by the linear variable filter, which has a 10 nm band pass and a center wavelength that varies from 2.18-2.38 m (4600-4200 cm
) over the length of the detector array. The sensor assembly is a monolithic design requiring no coupling optics. In the present system, the LED running with 100 mA of drive current delivers 20 nW of power to each of the detector pixels, which have a noise-equivalent-power of 3 pW/Hz
. This is sufficient to provide a signal-to-noise ratio of 4500 Hz
under detector-noise limited conditions. This signal-to-noise ratio corresponds to a spectral noise level less than 10 AU for a five minute integration, which should be sufficient for sub-millimolar glucose detection.
Details
- Title: Subtitle
- Optical microsensor for continuous glucose measurements in interstitial fluid
- Creators
- Jonathon T Olesberg - University of IowaChuanshun Cao - University of IowaJeffrey R Yager - University of IowaJohn P Prineas - University of IowaChris Coretsopoulos - University of IowaMark A Arnold - University of IowaLinda J Olafsen - University of KansasMichael Santilli - University of Kansas
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.6094(1), pp.609403-6094010
- Conference
- Optical Diagnostics and Sensing VI
- DOI
- 10.1117/12.646751
- ISSN
- 0277-786X
- Language
- English
- Date published
- 02/09/2006
- Academic Unit
- Center for Biocatalysis and Bioprocessing; Chemistry; Physics and Astronomy; Chemical and Biochemical Engineering; Fraternal Order of Eagles Diabetes Research Center; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984197328002771
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