Dataset
Dataset for: Correlation of telomere length in brain tissue with peripheral tissues in living human subjects.
University of Iowa
06/24/2025
DOI: 10.25820/data.007801
Abstract
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates with that in brain is not known. Saliva, buccal, blood, and brain samples were collected at time points before, during, and after subjects undergoing neurosurgery (n = 35) for intractable epilepsy. DNA was isolated from samples and average telomere length assessed by qPCR. Correlations of telomere length between tissue samples were calculated across subjects. When data were stratified by sex, saliva telomere length correlated with brain telomere length in males only. Buccal telomere length correlated with brain telomere length when males and females were combined. These findings indicate that in living subjects, telomere length in peripheral tissues variably correlates with that in brain and may be dependent on sex. Peripheral tissue telomere length may provide insight into brain telomere length, relevant to assessment of brain disorder pathophysiology.
Details
- Title: Subtitle
- Dataset for: Correlation of telomere length in brain tissue with peripheral tissues in living human subjects.
- Creators
- Annemarie Carver (Corresponding Author)Benjamin W Q Hing (Project Member) - University of Iowa, Molecular Physiology and BiophysicsBenjamin A Elser - University of IowaStephanie J Lussier - University of IowaTakehiko Yamanashi - University of IowaMatthew A Howard III - University of Iowa, Iowa Neuroscience InstituteHiroto Kawasaki - University of Iowa, NeurosurgeryGen Shinozaki - University of Iowa, PsychiatryHanna E Stevens (Project Leader) - University of Iowa, Iowa Neuroscience Institute
- Contributors
- Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
- Resource Type
- Dataset
- Publisher
- University of Iowa
- DOI
- 10.25820/data.007801
- Grants
- Grant note
- Also supported by the Roy J. Carver Charitable Trust
- Language
- English
- Date collected
- 2022–2023
- Date published
- 06/24/2025
- Academic Unit
- Neurology; Psychiatry; Iowa Neuroscience Institute; Humanities and Social Sciences/Scholarly Impact; Neurosurgery; Otolaryngology
- Record Identifier
- 9984465954302771
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