Journal article
Correlation of telomere length in brain tissue with peripheral tissues in living human subjects
Frontiers in molecular neuroscience, Vol.17, 1303974
03/07/2024
DOI: 10.3389/fnmol.2024.1303974
PMCID: PMC10954899
PMID: 38516039
Abstract
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates with that in brain is not known. Saliva, buccal, blood, and brain samples were collected at time points before, during, and after subjects undergoing neurosurgery (n=35) for intractable epilepsy. DNA was isolated from samples and average telomere length assessed by qPCR. Correlations of telomere length between tissue samples were calculated across subjects. When data were stratified by sex, saliva telomere length correlated with brain telomere length in males only. Buccal telomere length correlated with brain telomere length when males and females were combined. These findings indicate that in living subjects, telomere length in peripheral tissues variably correlates with that in brain and may be dependent on sex. Peripheral tissue telomere length may provide insight into brain telomere length, relevant to assessment of brain disorder pathophysiology.
Details
- Title: Subtitle
- Correlation of telomere length in brain tissue with peripheral tissues in living human subjects
- Creators
- Annemarie Carver - University of IowaBenjamin Hing - University of IowaBenjamin Elser - University of IowaStephanie Lussier - University of IowaTakehiko Yamanashi - University of IowaMatthew A Howard III - University of IowaHiroto Kawasaki - University of IowaGen Shinozaki - University of IowaHanna Stevens - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Frontiers in molecular neuroscience, Vol.17, 1303974
- Publisher
- Frontiers Research Foundation
- DOI
- 10.3389/fnmol.2024.1303974
- PMID
- 38516039
- PMCID
- PMC10954899
- eISSN
- 1662-5099
- Language
- English
- Date published
- 03/07/2024
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984567867602771
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