Dataset for Significant Metabolic Alterations in Mouse Dams Exposed to an Environmental Mixture of Polychlorinated Biphenyls (PCBs) During Gestation and Lactation: Insights into PCB and Metabolite Profiles

Xueshu Li; Youjun Park Suh; Rebecca J. Wilson; Pamela J Lein; Julia Yue Cui; Hans-Joachim Lehmler

doi:10.25820/data.007305

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Dataset for Significant Metabolic Alterations in Mouse Dams Exposed to an Environmental Mixture of Polychlorinated Biphenyls (PCBs) During Gestation and Lactation: Insights into PCB and Metabolite Profiles

Xueshu Li, Youjun Park Suh, Rebecca J. Wilson, Pamela J Lein, Julia Yue Cui and Hans-Joachim Lehmler

University of Iowa

09/20/2024

DOI: 10.25820/data.007305

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01_Readme_PCB_and_metabolites_in_dam_serum16.84 kBDownload View

READMEDescription of the dataset, including abstract, file list, and methods.Open Data Commons Attribution (ODC-By) V1.0, Open Access

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02_DataDictionary3.33 kBDownload View

Data DictionaryOpen Data Commons Attribution (ODC-By) V1.0, Open Access

csv

D13_PCB_and_MeO-PCB_SubstanceIdentifiers188.19 kBDownload View

This datasheet contains the unique PCB and MeO-CPB identifiers (SMILES, InChIKey, InChI, CAS RN, PubChem ID, DSSTox ID).Open Data Commons Attribution (ODC-By) V1.0, Open Access

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Link to Globus for downloading the data filesView

Data files are accessible via this link to Globus. Download from Globus via web browser, or Globus app.Open Data Commons Attribution (ODC-By) V1.0

Abstract

Polychlorinated biphenyls (PCBs) and their metabolites are linked to developmental neurotoxicity, but their levels in the gestational and lactational environment remain unexplored. This study investigated the effects of dietary exposure to the Fox River Mixture (FRM) on serum levels of PCBs and their metabolites in female C57BL/6J mice. The mice were exposed to 0, 0.1, 1, and 6 mg/kg body weight of FRM beginning two weeks before mating and throughout gestation and lactation. Serum samples from the dams were analyzed using gas chromatography-mass spectrometry (GC-MS/MS) and liquid chromatography-high resolution mass spectrometry (LC-HRMS). This dataset includes the data from the targeted analysis of PCBs and OH-PCBs by GC-MS-MS, untargeted analysis of polar PCB metabolites with negative mode LC-HRMS, the quality assurance and quality control data, and the corresponding raw data acquired by GC-MS-MS and LC-HRMS.

Metabolites

PCBs

Polychlorinated biphenyls

Neurotoxicity

Dietary exposure

Hydroxylated polychlorinated biphenyls

Gestation

Rattus

Details

Title: Subtitle: Dataset for Significant Metabolic Alterations in Mouse Dams Exposed to an Environmental Mixture of Polychlorinated Biphenyls (PCBs) During Gestation and Lactation: Insights into PCB and Metabolite Profiles
Creators: Xueshu Li - University of Iowa, Occupational and Environmental Health
Youjun Park Suh - University of Washington
Rebecca J. Wilson - University of California, Davis
Pamela J Lein - University of California, Davis
Julia Yue Cui - University of Washington
Hans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
Contributors: Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
Resource Type: Dataset
DOI: 10.25820/data.007305
Publisher: University of Iowa
Grants: Environmental Health Sciences Research Center, P30ES005605, National Institutes of Health (United States, Bethesda) - NIH
PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?, R01ES031098, National Institutes of Health (United States, Bethesda) - NIH
Molecular and Cellular Basis of PCB Developmental Neurotoxicity, R01ES014901, National Institutes of Health (United States, Bethesda) - NIH
Environmental factors in pathobiology of dementia: the role of PCB exposure, microbiome, and tissue barrier dysfunction, R01ES034691, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date collected: 07/01/2022–08/01/2023
Date published: 09/20/2024
Academic Unit: Occupational and Environmental Health; Iowa Neuroscience Institute; Humanities and Social Sciences/Scholarly Impact
Record Identifier: 9984656030502771

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Dataset for Significant Metabolic Alterations in Mouse Dams Exposed to an Environmental Mixture of Polychlorinated Biphenyls (PCBs) During Gestation and Lactation: Insights into PCB and Metabolite Profiles

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