Journal article
Significant Metabolic Alterations in Mouse Dams Exposed to an Environmental Mixture of Polychlorinated Biphenyls (PCBs) During Gestation and Lactation: Insights into PCB and Metabolite Profiles
Environmental toxicology and pharmacology, Vol.111, p.104567
10/2024
DOI: 10.1016/j.etap.2024.104567
Abstract
Polychlorinated biphenyls (PCBs) and metabolites are linked to developmental neurotoxicity, but their levels in the gestational and lactational environment remain unexplored. This study investigated the effects of dietary exposure to the Fox River Mixture (FRM) on serum levels of PCBs and their metabolites in female C57BL/6J mice. Mice were exposed to 0.1, 1.0, or 6.0mg/kg body weight/day of FRM beginning two weeks before mating and throughout gestation and lactation. Serum samples collected from the dams at weaning were analyzed using gas chromatograph-mass spectrometry and nontarget liquid chromatography-high resolution mass spectrometry. Results showed complex and dose-dependent differences in PCB and metabolite profiles. Untargeted metabolomics revealed alterations in metabolites involved in glucuronidation. Network analysis suggested disturbances in heme and amino acid metabolism associated with higher chlorinated PCBs. These findings suggested that PCBs and metabolites present in the gestational and lactation environment of mice may contribute to developmental neurotoxicity in rodents.
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•PCBs and metabolites were measured in serum from dams exposed to a PCB mixture•PCB but not OH-PCB serum profiles changed with the PCB dose•Serum contained complex sulfated and methylated PCB metabolite mixtures•PCB exposure altered serum levels of metabolites in the glucuronidation pathway•Higher chlorinated PCBs affected heme and amino acid metabolic pathways
Details
- Title: Subtitle
- Significant Metabolic Alterations in Mouse Dams Exposed to an Environmental Mixture of Polychlorinated Biphenyls (PCBs) During Gestation and Lactation: Insights into PCB and Metabolite Profiles
- Creators
- Xueshu Li - University of Iowa, Occupational and Environmental HealthYoujun Suh - University of WashingtonRebecca Wilson - University of California, DavisPamela J. Lein - University of California, DavisJulia Y. Cui - University of WashingtonHans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
- Resource Type
- Journal article
- Publication Details
- Environmental toxicology and pharmacology, Vol.111, p.104567
- DOI
- 10.1016/j.etap.2024.104567
- ISSN
- 1382-6689
- eISSN
- 1872-7077
- Publisher
- Elsevier B.V
- Grant note
- National Institutes of Health: R01ES014901, R01ES031098, R01ES034691 Environmental Health Sciences Research Center: P30ES005605 Iowa Superfund Research Program: P42ES013661
The work was supported by the National Institutes of Health [grant numbers R01ES014901, R01ES031098, and R01ES034691] and performed in facilities of the Environmental Health Sciences Research Center [P30ES005605] and the Iowa Superfund Research Program [P42ES013661]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies listed above.
- Language
- English
- Date published
- 10/2024
- Academic Unit
- Occupational and Environmental Health; Iowa Superfund Research Program
- Record Identifier
- 9984703341102771
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