Dataset for assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: age and brain region differences

Xueshu Li; Marco M Hefti; Rachel F Marek; Keri C Hornbuckle; Kai Wang; Hans-Joachim Lehmler

doi:10.25820/data.006169

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Dataset for assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: age and brain region differences

Xueshu Li, Marco M Hefti, Rachel F Marek, Keri C Hornbuckle, Kai Wang and Hans-Joachim Lehmler

University of Iowa

05/31/2022

DOI: 10.25820/data.006169

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Abstract

The levels of polychlorinated biphenyls_PCBs) and hydroxylated polychlorinated biphenyls_OH-PCBs) in postmortem human brain tissues from Iowa were measured by GC-MS-MS_Triple Quad) in the multiple monitoring mode_MRM. Both PCBs and OH-PCBs_as MeO-PCBs) were determined with a GC-MS-MS equipped with an SPB-Octyl capillary column, and a subset of OH-PCB samples were reanalyzed with a GC-MS-MS_MRM) equipped with a DB1701 capillary column. This dataset includes the information about samples from individual donors, including age, gender, and the weight of tissued used for this study. The quality assurance and quality control_QA/QC) of data included limits of detections_LOD) of PCBs and OH-PCBs, recovery rates of PCB and OH-PCB surrogate standards_SS), and data of Reference Standard Materials_RSM 1957, NIST) analyzed in parallel with actual samples. Both the raw data_as ng) and the corresponding tissue wet weight-adjusted data_concentration of PCBs and OH-PCBs as pico-gram per gram) were included in this dataset. The neurotoxic equivalency quotients_NEQ) of PCB groups by homologs and ortho-chlorine numbers were also calculated and included based on the published NEQ factors with single and multiple mechanisms.

Human brain

PCBs

Polychlorinated biphenyls

Hydroxylated polychlorinated biphenyls

OH-PCBs

Neurotoxic equivalency quotients

Synthesis Core

Analytical Core

Data Management and Analysis Core

Details

Title: Subtitle: Dataset for assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: age and brain region differences
Creators: Xueshu Li - University of Iowa, Occupational and Environmental Health
Marco M Hefti - University of Iowa, Pathology
Rachel F Marek - University of Iowa, IIHR--Hydroscience and Engineering
Keri C Hornbuckle - University of Iowa, Civil and Environmental Engineering
Kai Wang - University of Iowa, Biostatistics
Hans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
Resource Type: Dataset
Publisher: University of Iowa
DOI: 10.25820/data.006169
Grants: Airborne PCBs: Sources, Exposures, Toxicities, Remediation, P42ES013661, National Institutes of Health (United States, Bethesda) - NIH
Environmental Health Sciences Research Center, P30ES005605, National Institutes of Health (United States, Bethesda) - NIH
PCB Enantiomers Implicated in Neurodevelopmental Disorders: Identification of Individual Metabolic Factors that Determine Risk and Vulnerability, R21ES027169, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date collected: 11/01/2018 - 07/01/2019
Date published: 05/31/2022
Academic Unit: Biostatistics; Civil and Environmental Engineering; IIHR--Hydroscience and Engineering; Interdisciplinary Graduate Program in Human Toxicology; Iowa Neuroscience Institute; Iowa Superfund Research Program; Occupational and Environmental Health; Pathology
Record Identifier: 9984236058902771

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Dataset for assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: age and brain region differences

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