Neurotoxic and Behavioral Outcomes Data Following Polychlorinated Biphenyl (PCB) Exposure in Post-Weaned Rodents

Nicole M Breese; Riley J Samuelson; Sophia G. Heim; Hans-Joachim Lehmler

doi:10.25820/data.008102

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Neurotoxic and Behavioral Outcomes Data Following Polychlorinated Biphenyl (PCB) Exposure in Post-Weaned Rodents

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Neurotoxic and Behavioral Outcomes Data Following Polychlorinated Biphenyl (PCB) Exposure in Post-Weaned Rodents

Nicole M Breese, Riley J Samuelson, Sophia G. Heim and Hans-Joachim Lehmler

University of Iowa

11/05/2025

DOI: 10.25820/data.008102

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01_ReadMe_Review_NB15.77 kBDownload View

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02_Data_Dictionary_ChatGPT_Abstracts1.53 kBDownload View

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03_Dataset_ChatGPT_Abstracts870.70 kBDownload View

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04_Data_Dictionary_ChatGPT_Methods1.05 kBDownload View

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05_Dataset_ChatGPT_Methods1.18 MBDownload View

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Abstract

This dataset accompanies a scoping review examining the neurotoxic outcomes of post-weaning exposure to polychlorinated biphenyls (PCBs) in rodent models. The dataset compiles results from a systematic literature search across PubMed, Embase, and Scopus, conducted according to PRISMA guidelines. Screening and data extraction were performed through a hybrid human–AI workflow that integrated manual review with automated screening via ChatGPT. The dataset includes ChatGPT’s classification outputs for title/abstract and methods screening, reviewer selections for calculating inter-rater reliability (Cohen’s and Fleiss’ kappa), and extracted data from full-text analyses of the included studies. Thirty-five studies met the inclusion criteria, representing diverse PCB congeners and mixtures administered to mice and rats during adolescence or adulthood. Extracted parameters include species, strain, sex, exposure window, dose, route of administration, and reported neurotoxic and behavioral outcomes. Neurotoxic endpoints encompassed oxidative stress, calcium signaling disruption, alterations in neurotransmitter levels, apoptosis, and changes in gene expression, while behavioral outcomes included effects on locomotion, anxiety, learning, memory, and cognitive flexibility. The dataset provides a record of screening decisions, methodological reproducibility, and synthesized study characteristics.

Scoping Review

post-weaning exposure

Rodent models

Polychlorinated biphenyls'

PCBs

Neurotoxicity

Human-AI workflow

Details

Title: Subtitle: Neurotoxic and Behavioral Outcomes Data Following Polychlorinated Biphenyl (PCB) Exposure in Post-Weaned Rodents
Creators: Nicole M Breese - University of Iowa
Riley J Samuelson - University of Iowa, Hardin Library
Sophia G. Heim - University of Iowa
Hans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
Contributors: Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
Resource Type: Dataset
DOI: 10.25820/data.008102
Publisher: University of Iowa
Grants: Airborne PCBs: Sources, Exposures, Toxicities, Remediation, P42ES013661, National Institutes of Health (United States, Bethesda) - NIH
Environmental Health Sciences Research Center, P30ES005605, National Institutes of Health (United States, Bethesda) - NIH
PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?, R01ES031098, National Institutes of Health (United States, Bethesda) - NIH
Molecular and Cellular Basis of PCB Developmental Neurotoxicity, R01ES014901, National Institutes of Health (United States, Bethesda) - NIH
Environmental factors in pathobiology of dementia: the role of PCB exposure, microbiome, and tissue barrier dysfunction, R01ES034691, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date collected: 11/01/2023–09/08/2025
Date published: 11/05/2025
Academic Unit: Public Health Administration; Occupational and Environmental Health; Iowa Neuroscience Institute; Humanities and Social Sciences/Scholarly Impact; Iowa Superfund Research Program; Hardin Library
Record Identifier: 9985015379302771

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