Dataset
Neurotoxic and Behavioral Outcomes Data Following Polychlorinated Biphenyl (PCB) Exposure in Post-Weaned Rodents
University of Iowa
11/05/2025
DOI: 10.25820/data.008102
Abstract
This dataset accompanies a scoping review examining the neurotoxic outcomes of post-weaning exposure to polychlorinated biphenyls (PCBs) in rodent models. The dataset compiles results from a systematic literature search across PubMed, Embase, and Scopus, conducted according to PRISMA guidelines. Screening and data extraction were performed through a hybrid human–AI workflow that integrated manual review with automated screening via ChatGPT. The dataset includes ChatGPT’s classification outputs for title/abstract and methods screening, reviewer selections for calculating inter-rater reliability (Cohen’s and Fleiss’ kappa), and extracted data from full-text analyses of the included studies. Thirty-five studies met the inclusion criteria, representing diverse PCB congeners and mixtures administered to mice and rats during adolescence or adulthood. Extracted parameters include species, strain, sex, exposure window, dose, route of administration, and reported neurotoxic and behavioral outcomes. Neurotoxic endpoints encompassed oxidative stress, calcium signaling disruption, alterations in neurotransmitter levels, apoptosis, and changes in gene expression, while behavioral outcomes included effects on locomotion, anxiety, learning, memory, and cognitive flexibility. The dataset provides a record of screening decisions, methodological reproducibility, and synthesized study characteristics.
Details
- Title: Subtitle
- Neurotoxic and Behavioral Outcomes Data Following Polychlorinated Biphenyl (PCB) Exposure in Post-Weaned Rodents
- Creators
- Nicole M Breese - University of IowaRiley J Samuelson - University of Iowa, Hardin LibrarySophia G. Heim - University of IowaHans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
- Contributors
- Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
- Resource Type
- Dataset
- DOI
- 10.25820/data.008102
- Publisher
- University of Iowa
- Grants
- Language
- English
- Date collected
- 11/01/2023–09/08/2025
- Date published
- 11/05/2025
- Academic Unit
- Public Health Administration; Occupational and Environmental Health; Humanities and Social Sciences/Scholarly Impact; Iowa Superfund Research Program; Hardin Library
- Record Identifier
- 9985015379302771
Metrics
3 File views/ downloads
38 Record Views