Journal article
A Road Map to Understanding Cardiovascular Disease in Diabetes: From the AHA Strategically Focused Research Network in Cardiometabolic Health and Type 2 Diabetes
Circulation research, Vol.138(2), e325798
01/16/2026
DOI: 10.1161/CIRCRESAHA.125.325798
PMID: 41538415
Abstract
Despite major advances in medical therapies and prevention strategies, the risk of cardiovascular complications in patients with both type I and type II diabetes remains substantially elevated. In 2019, the American Heart Association sought applications for a Strategically Focused Research Network on Cardiometabolic Health and Type 2 Diabetes. In 2020, 4 centers were named, including Brigham and Women's Hospital, Johns Hopkins University, New York University, and the University of Iowa. These centers performed basic, translational, and clinical studies to provide insights to explain the over 2-fold risk of cardiovascular complications in diabetes. Clinical studies and studies in cells and animals aimed to uncover new mechanisms responsible for disease development. Studies using human populations sought to uncover new biomarkers to prognosticate risk. In this review, we discuss several key issues and current and developing methods to understand why diabetes drives atherosclerotic cardiovascular disease and heart failure. Both human data and experimental models are considered. We integrate a review of these topics with work from the Strategically Focused Research Network and conclude with suggestions for identifying novel risk factors and future experimental research.
Details
- Title: Subtitle
- A Road Map to Understanding Cardiovascular Disease in Diabetes: From the AHA Strategically Focused Research Network in Cardiometabolic Health and Type 2 Diabetes
- Creators
- E Dale Abel - University of California, Los AngelesRexford S Ahima - Johns Hopkins UniversityEthan J Anderson - University of IowaDavid D Berg - Brigham and Women's HospitalJeffrey S Berger - New York UniversitySaumya Das - Massachusetts General HospitalMark W Feinberg - Brigham and Women's HospitalEdward A Fisher - New York UniversityMichael S Garshick - New York UniversityChiara Giannarelli - New York UniversityIra J Goldberg - New York UniversityNaomi M Hamburg - Boston University School of MedicineSangwon F Kim - Johns Hopkins MedicineFilipe A Moura - Brigham and Women's HospitalChiadi E Ndumele - Johns Hopkins MedicineJonathan D Newman - New York UniversityMarc S Sabatine - Brigham and Women's HospitalElizabeth Selvin - Johns Hopkins UniversityRavi Shah - Vanderbilt University Medical Center
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.138(2), e325798
- DOI
- 10.1161/CIRCRESAHA.125.325798
- PMID
- 41538415
- NLM abbreviation
- Circ Res
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Grant note
- American Heart Association: 20SFRN35110004, 20SFRN35120152, 20SFRN35120123, 20SFRN35210245
The authors are supported by the following Strategically Focused Research Network grants from the American Heart Association: 20SFRN35110004 to M.W. Feinberg, N.M. Hamburg, M.S. Sabatine; 20SFRN35120152 to R.S. Ahima, C.E. Ndumele, E. Selvin; 20SFRN35120123 to E.D. Abel, E.J. Anderson, S. Das, R. Shah: and 20SFRN35210245 to J.S. Berger, E.A. Fisher, C. Giannarelli, I.J. Goldberg, and J. Newman.
- Language
- English
- Date published
- 01/16/2026
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9985121502302771
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