Bone density and alendronate effects in Duchenne muscular dystrophy patients

Caroline Houston; Katherine Mathews; Amal Shibli-Rahhal

doi:10.1002/mus.23948

Back

Bone density and alendronate effects in Duchenne muscular dystrophy patients

Journal article

Peer reviewed

Bone density and alendronate effects in Duchenne muscular dystrophy patients

Caroline Houston, Katherine Mathews and Amal Shibli-Rahhal

Muscle & nerve, Vol.49(4), pp.506-511

04/2014

DOI: 10.1002/mus.23948

PMID: 23835890

View Online

Abstract

Patients with DMD have low bone mineral density (BMD) and are at high risk for fractures. We examined changes in BMD and the effects of alendronate in DMD patients treated at our institution in the last decade. Retrospective cohort study of 39 DMD patients. Patients had screening dual energy x-ray absorptiometry (DXA) at an average age of 12 years. The vast majority had low Z-scores at the total hip and lumbar spine. Patients treated with glucocorticoids had a significantly lower Z-score at the spine than those not treated with glucocorticoids. Z-scores at the hip trended down without alendronate (P = 0.07) and trended up with alendronate (P = 0.4). By age 12 years, most patients with DMD had low Z-scores. They may have benefitted from earlier screening. Z-score at the hip trended downward without alendronate and trended upward (stabilized) with alendronate, but these trends were not statistically significant.

Absorptiometry, Photon - trends

Bone Density - physiology

Follow-Up Studies

Muscular Dystrophy, Duchenne - drug therapy

Humans

Bone Density Conservation Agents - therapeutic use

Child, Preschool

Male

Treatment Outcome

Alendronate - therapeutic use

Bone Density Conservation Agents - pharmacology

Muscular Dystrophy, Duchenne - diagnostic imaging

Young Adult

Bone Density - drug effects

Adolescent

Alendronate - pharmacology

Adult

Retrospective Studies

Child

Cohort Studies

Details

Title: Subtitle: Bone density and alendronate effects in Duchenne muscular dystrophy patients
Creators: Caroline Houston - Division of Endocrinology, E 426 GH, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa, 52242, USA
Katherine Mathews
Amal Shibli-Rahhal
Resource Type: Journal article
Publication Details: Muscle & nerve, Vol.49(4), pp.506-511
DOI: 10.1002/mus.23948
PMID: 23835890
NLM abbreviation: Muscle Nerve
ISSN: 0148-639X
eISSN: 1097-4598
Publisher: United States
Language: English
Date published: 04/2014
Academic Unit: Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics); Medicine Administration; Internal Medicine
Record Identifier: 9984001133002771

Metrics

71 Record Views

33 Times Cited - Web of Science