Brain structure in juvenile-onset Huntington disease

Alexander Tereshchenko; Vincent Magnotta; Eric Epping; Katherine Mathews; Patricia Espe-Pfeifer; Erin Martin; Jeffrey Dawson; Wenzhen Duan; Peg Nopoulos

doi:10.1212/wnl.0000000000007355

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Brain structure in juvenile-onset Huntington disease

Journal article

Open access

Peer reviewed

Brain structure in juvenile-onset Huntington disease

Alexander Tereshchenko, Vincent Magnotta, Eric Epping, Katherine Mathews, Patricia Espe-Pfeifer, Erin Martin, Jeffrey Dawson, Wenzhen Duan and Peg Nopoulos

Neurology, Vol.92(17), pp.e1939-e1947

04/23/2019

DOI: 10.1212/wnl.0000000000007355

PMCID: PMC6511077

PMID: 30971481

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Abstract

To assess brain morphometry in a sample of patients with juvenile-onset Huntington disease (JOHD) and several mouse models of Huntington disease (HD) that likely represent the human JOHD phenotype.

Magnetic Resonance Imaging

Brain - diagnostic imaging

Humans

Huntington Disease - pathology

Child, Preschool

Male

Organ Size - physiology

Gray Matter - diagnostic imaging

White Matter - pathology

Huntington Disease - diagnostic imaging

Young Adult

White Matter - diagnostic imaging

Animals

Adolescent

Gray Matter - pathology

Brain - pathology

Adult

Female

Mice

Child

Disease Models, Animal

Details

Title: Subtitle: Brain structure in juvenile-onset Huntington disease
Creators: Alexander Tereshchenko - From the Departments of Psychiatry (A.T., E.E., V.M., P.E.-P., E.M.), Radiology (V.M.), Neurology (K.M., P.E.-P.), and Pediatrics (K.M.), University of Iowa Hospitals and Clinics, Iowa City; Department of Biostatistics (J.D.), University of Iowa College of Public Health, Iowa City; and Department of Psychiatry and Behavioral Sciences (W.D.), Johns Hopkins University, Baltimore, MD
Vincent Magnotta - From the Departments of Psychiatry (A.T., E.E., V.M., P.E.-P., E.M.), Radiology (V.M.), Neurology (K.M., P.E.-P.), and Pediatrics (K.M.), University of Iowa Hospitals and Clinics, Iowa City; Department of Biostatistics (J.D.), University of Iowa College of Public Health, Iowa City; and Department of Psychiatry and Behavioral Sciences (W.D.), Johns Hopkins University, Baltimore, MD
Eric Epping - From the Departments of Psychiatry (A.T., E.E., V.M., P.E.-P., E.M.), Radiology (V.M.), Neurology (K.M., P.E.-P.), and Pediatrics (K.M.), University of Iowa Hospitals and Clinics, Iowa City; Department of Biostatistics (J.D.), University of Iowa College of Public Health, Iowa City; and Department of Psychiatry and Behavioral Sciences (W.D.), Johns Hopkins University, Baltimore, MD
Katherine Mathews - From the Departments of Psychiatry (A.T., E.E., V.M., P.E.-P., E.M.), Radiology (V.M.), Neurology (K.M., P.E.-P.), and Pediatrics (K.M.), University of Iowa Hospitals and Clinics, Iowa City; Department of Biostatistics (J.D.), University of Iowa College of Public Health, Iowa City; and Department of Psychiatry and Behavioral Sciences (W.D.), Johns Hopkins University, Baltimore, MD
Patricia Espe-Pfeifer - From the Departments of Psychiatry (A.T., E.E., V.M., P.E.-P., E.M.), Radiology (V.M.), Neurology (K.M., P.E.-P.), and Pediatrics (K.M.), University of Iowa Hospitals and Clinics, Iowa City; Department of Biostatistics (J.D.), University of Iowa College of Public Health, Iowa City; and Department of Psychiatry and Behavioral Sciences (W.D.), Johns Hopkins University, Baltimore, MD
Erin Martin - From the Departments of Psychiatry (A.T., E.E., V.M., P.E.-P., E.M.), Radiology (V.M.), Neurology (K.M., P.E.-P.), and Pediatrics (K.M.), University of Iowa Hospitals and Clinics, Iowa City; Department of Biostatistics (J.D.), University of Iowa College of Public Health, Iowa City; and Department of Psychiatry and Behavioral Sciences (W.D.), Johns Hopkins University, Baltimore, MD
Jeffrey Dawson - From the Departments of Psychiatry (A.T., E.E., V.M., P.E.-P., E.M.), Radiology (V.M.), Neurology (K.M., P.E.-P.), and Pediatrics (K.M.), University of Iowa Hospitals and Clinics, Iowa City; Department of Biostatistics (J.D.), University of Iowa College of Public Health, Iowa City; and Department of Psychiatry and Behavioral Sciences (W.D.), Johns Hopkins University, Baltimore, MD
Wenzhen Duan - From the Departments of Psychiatry (A.T., E.E., V.M., P.E.-P., E.M.), Radiology (V.M.), Neurology (K.M., P.E.-P.), and Pediatrics (K.M.), University of Iowa Hospitals and Clinics, Iowa City; Department of Biostatistics (J.D.), University of Iowa College of Public Health, Iowa City; and Department of Psychiatry and Behavioral Sciences (W.D.), Johns Hopkins University, Baltimore, MD
Peg Nopoulos - From the Departments of Psychiatry (A.T., E.E., V.M., P.E.-P., E.M.), Radiology (V.M.), Neurology (K.M., P.E.-P.), and Pediatrics (K.M.), University of Iowa Hospitals and Clinics, Iowa City; Department of Biostatistics (J.D.), University of Iowa College of Public Health, Iowa City; and Department of Psychiatry and Behavioral Sciences (W.D.), Johns Hopkins University, Baltimore, MD. peggy-nopoulos@uiowa.edu
Resource Type: Journal article
Publication Details: Neurology, Vol.92(17), pp.e1939-e1947
DOI: 10.1212/wnl.0000000000007355
PMID: 30971481
PMCID: PMC6511077
NLM abbreviation: Neurology
ISSN: 0028-3878
eISSN: 1526-632X
Publisher: United States
Grant note: T32 GM007337 / NIGMS NIH HHS
Language: English
Date published: 04/23/2019
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Public Health Administration; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Neurology (Pediatrics)
Record Identifier: 9984003447802771

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