Case Report: Severe COVID-19 in a Kidney Transplant Recipient Without Humoral Response to SARS-CoV-2 mRNA Vaccine Series

Masaaki Yamada; Eiyu Matsumoto; Christie P Thomas; Jennifer R Carlson; Stacey J Klutts; Bharat Kumar; Judy A Streit; Melissa L Swee

doi:10.1097/TXD.0000000000001193

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Case Report: Severe COVID-19 in a Kidney Transplant Recipient Without Humoral Response to SARS-CoV-2 mRNA Vaccine Series

Journal article

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Peer reviewed

Case Report: Severe COVID-19 in a Kidney Transplant Recipient Without Humoral Response to SARS-CoV-2 mRNA Vaccine Series

Masaaki Yamada, Eiyu Matsumoto, Christie P Thomas, Jennifer R Carlson, Stacey J Klutts, Bharat Kumar, Judy A Streit and Melissa L Swee

Transplantation direct, Vol.7(9), pp.e743-e743

09/01/2021

DOI: 10.1097/TXD.0000000000001193

PMCID: PMC8352604

PMID: 34386580

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Abstract

The ongoing global pandemic of coronavirus disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted the rapid development of several safe and effective vaccines.1 The earliest to receive emergency use authorization by the US Food and Drug Administration were 2 novel mRNA vaccines. The short-term efficacy of these mRNA vaccines from their phase 3 trials has been comparable with that of highly effective conventional vaccines. In healthy trial participants, these mRNA vaccines reduced symptomatic SARS-CoV-2 infection by over 90%.2-4 However, the efficacy and long-term immunogenicity of SARS-CoV-2 mRNA vaccines have not yet been thoroughly studied in immunocompromised populations. One of the earliest studies reported reduced humoral response to mRNA vaccine in solid organ transplant (SOT) recipients.5 We report a case of a long-term kidney transplant recipient on stable maintenance immunosuppression who acquired COVID-19 with onset of symptoms about 11 d after his second dose of SARS-CoV-2 mRNA vaccine.

Details

Title: Subtitle: Case Report: Severe COVID-19 in a Kidney Transplant Recipient Without Humoral Response to SARS-CoV-2 mRNA Vaccine Series
Creators: Masaaki Yamada - University of Iowa
Eiyu Matsumoto - University of Iowa
Christie P Thomas - University of Iowa
Jennifer R Carlson - Iowa City VA Medical Center
Stacey J Klutts - University of Iowa
Bharat Kumar - University of Iowa
Judy A Streit - University of Iowa
Melissa L Swee - University of Iowa
Resource Type: Journal article
Publication Details: Transplantation direct, Vol.7(9), pp.e743-e743
DOI: 10.1097/TXD.0000000000001193
PMID: 34386580
PMCID: PMC8352604
NLM abbreviation: Transplant Direct
ISSN: 2373-8731
eISSN: 2373-8731
Publisher: Wolters Kluwer
Language: English
Date published: 09/01/2021
Academic Unit: Infectious Diseases; Stead Family Department of Pediatrics; Pathology; Obstetrics and Gynecology; Nephrology; Immunology; Internal Medicine
Record Identifier: 9984186436002771

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