Journal article
Deconjugation of Polychlorinated Biphenyl Sulfates to Hydroxylated PCBs by Anaerobically Cultured Mouse and Human Gut Microbiota
Chemical research in toxicology, Vol.38(4), pp.557-560
04/21/2025
DOI: 10.1021/acs.chemrestox.5c00016
PMCID: PMC12015953
PMID: 40130436
Appears in UI Libraries Support Open Access
Abstract
The role of the gut microbiome in metabolizing polychlorinated biphenyls (PCBs), toxic environmental contaminants, and their metabolites remains unclear. This study used mouse and human microbiomes in anaerobic cultures to investigate the metabolism of PCB sulfate to hydroxylated PCBs (OH-PCBs). All microbiomes enzymatically hydrolyzed PCB sulfates. Higher chlorinated PCB sulfates were metabolized more readily. Male mouse microbiomes exhibited more PCB sulfate hydrolysis to OH-PCBs than female mouse microbiomes. Human microbiomes metabolized PCB sulfates to a more considerable extent than mouse microbiomes. They also showed variability in PCB sulfate metabolism, depending on the microbial communities. These findings suggest that the microbiome contributes to PCB metabolism.
Details
- Title: Subtitle
- Deconjugation of Polychlorinated Biphenyl Sulfates to Hydroxylated PCBs by Anaerobically Cultured Mouse and Human Gut Microbiota
- Creators
- Xueshu Li - University of IowaJoe J Lim - University of WashingtonCayen Rong - University of WashingtonHans-Joachim Lehmler - Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242, United StatesJulia Yue Cui - University of Washington
- Resource Type
- Journal article
- Publication Details
- Chemical research in toxicology, Vol.38(4), pp.557-560
- DOI
- 10.1021/acs.chemrestox.5c00016
- PMID
- 40130436
- PMCID
- PMC12015953
- NLM abbreviation
- Chem Res Toxicol
- ISSN
- 0893-228X
- eISSN
- 1520-5010
- Publisher
- American Chemical Society
- Grant note
- National Institute of Environmental Health SciencesNational Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health: ES005605, ES013661, ES014901, ES030197, ES031098, F31DK139707
This work wassupported by the National Institute of Environmental Health Sciences and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (ES005605, ES013661, ES014901,ES030197, ES031098, and F31DK139707). The content is solely the responsibilityof the authors and does not necessarily represent the official viewsof the National Institutes of Health.
- Language
- English
- Electronic publication date
- 03/25/2025
- Date published
- 04/21/2025
- Academic Unit
- Public Health Administration; Occupational and Environmental Health; Iowa Neuroscience Institute; Iowa Superfund Research Program
- Record Identifier
- 9984802411502771
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