Journal article
Dendritic Cell Membrane-Derived Nanovesicles for Targeted T Cell Activation
ACS omega, Vol.7(50), pp.46222-46233
12/20/2022
DOI: 10.1021/acsomega.2c04420
PMCID: PMC9773342
PMID: 36570199
Abstract
T cells play an integral role in the generation of an effective immune response and are responsible for clearing foreign microbes that have bypassed innate immune system defenses and possess cognate antigens. The immune response can be directed toward a desired target through the selective priming and activation of T cells. Due to their ability to activate a T cell response, dendritic cells and endogenous vesicles from dendritic cells are being developed for cancer immunotherapy treatment. However, current platforms, such as exosomes and synthetic nanoparticles, are limited by their production methods and application constraints. Here, we engineer nanovesicles derived from dendritic cell membranes with similar properties as dendritic cell exosomes via nitrogen cavitation. These cell-derived nanovesicles are capable of activating antigen-specific T cells through direct and indirect mechanisms. Additionally, these nanovesicles can be produced in large yields, overcoming production constraints that limit clinical application of alternative immunomodulatory vesicle or nanoparticle-based methods. Thus, dendritic cell-derived nanovesicles generated by nitrogen cavitation show potential as an immunotherapy platform to stimulate and direct T cell response.
Details
- Title: Subtitle
- Dendritic Cell Membrane-Derived Nanovesicles for Targeted T Cell Activation
- Creators
- Brock T. Harvey - University of KentuckyXu Fu - University of KentuckyLan Li - University of KentuckyKhaga R. Neupane - University of KentuckyNamrata Anand - University of KentuckyJill M. Kolesar - University of KentuckyChristopher I. Richards - University of Kentucky
- Resource Type
- Journal article
- Publication Details
- ACS omega, Vol.7(50), pp.46222-46233
- DOI
- 10.1021/acsomega.2c04420
- PMID
- 36570199
- PMCID
- PMC9773342
- NLM abbreviation
- ACS Omega
- ISSN
- 2470-1343
- eISSN
- 2470-1343
- Publisher
- Amer Chemical Soc
- Number of pages
- 12
- Grant note
- Kentucky Pediatric Cancer Research Trust Fund
- Language
- English
- Date published
- 12/20/2022
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984696552002771
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