Descriptive phenotype of obsessive compulsive symptoms in males with Duchenne Muscular Dystrophy

Angela J Lee; Edward T Buckingham; Aaron J Kauer; Katherine D Mathews

doi:10.1177/0883073818774439

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Descriptive phenotype of obsessive compulsive symptoms in males with Duchenne Muscular Dystrophy

Journal article

Open access

Peer reviewed

Descriptive phenotype of obsessive compulsive symptoms in males with Duchenne Muscular Dystrophy

Angela J Lee, Edward T Buckingham, Aaron J Kauer and Katherine D Mathews

Journal of child neurology, Vol.33(9), pp.572-579

08/2018

DOI: 10.1177/0883073818774439

PMCID: PMC6027593

PMID: 29779439

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https://www.ncbi.nlm.nih.gov/pmc/articles/6027593View

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Abstract

Increased rates of clinically significant internalizing disorders (obsessive compulsive disorder, anxiety, and depression) have been demonstrated in males with Duchenne muscular dystrophy, and a Duchenne muscular dystrophy neuropsychiatric syndrome has been suggested. While symptoms of depression are widely recognized, some of the other internalizing symptoms are less frequently identified. Through a retrospective chart review of 107 males with Duchenne muscular dystrophy, we identified 15 patients with obsessive compulsive disorder spectrum symptoms; 11 of those also had anxiety symptoms. Many of these patients received selective serotonin reuptake inhibitor treatment, commonly noting improvement in symptoms. Here we describe the clinical features of several patients in detail to facilitate early recognition and consideration for treatment for patients with Duchenne muscular dystrophy and internalizing psychiatric symptoms. The results of this cohort showed a significantly increased rate of obsessive compulsive disorder spectrum symptoms (14%) compared to the general population.

OCD

anxiety

internalizing disorders

SSRIs

Duchenne muscular dystrophy

Details

Title: Subtitle: Descriptive phenotype of obsessive compulsive symptoms in males with Duchenne Muscular Dystrophy
Creators: Angela J Lee - Departments of Pediatrics and Neurology, University of Iowa Hospital and Clinics, USA
Edward T Buckingham - Departments of Pediatrics and Neurology, University of Iowa Hospital and Clinics, USA
Aaron J Kauer - Departments of Pediatrics and Neurology, University of Iowa Hospital and Clinics, USA
Katherine D Mathews - Departments of Pediatrics and Neurology, University of Iowa Hospital and Clinics, USA
Resource Type: Journal article
Publication Details: Journal of child neurology, Vol.33(9), pp.572-579
DOI: 10.1177/0883073818774439
PMID: 29779439
PMCID: PMC6027593
NLM abbreviation: J Child Neurol
ISSN: 0883-0738
eISSN: 1708-8283
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: Paul D. Wellstone Muscular Dystrophy Cooperative R
Language: English
Date published: 08/2018
Academic Unit: Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
Record Identifier: 9984003463002771

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