Effects of inhalation of perfluorocarbon aerosol on oxygenation and pulmonary function compared to PGI2 inhalation in a sheep model of oleic acid-induced lung injury

M. Ragaller; J. Bleyl; U. Tschö; T. Winkler; M. Regner; S. Rasche; T. Koch; M. Albrecht

doi:10.1007/s001340100921

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Effects of inhalation of perfluorocarbon aerosol on oxygenation and pulmonary function compared to PGI2 inhalation in a sheep model of oleic acid-induced lung injury

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Effects of inhalation of perfluorocarbon aerosol on oxygenation and pulmonary function compared to PGI2 inhalation in a sheep model of oleic acid-induced lung injury

M. Ragaller, J. Bleyl, U. Tschö, T. Winkler, M. Regner, S. Rasche, T. Koch and M. Albrecht

Intensive care medicine, Vol.27(5), pp.889-897

05/2001

DOI: 10.1007/s001340100921

PMID: 11430546

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Abstract

Objective: To evaluate the effects of PFC aerosol compared to PGI2 aerosol and NaCl aerosol on gas exchange and lung mechanics in oleic acid-induced acute lung injury. Design: A prospective, controlled, randomised, in vivo animal laboratory study. Setting: Research laboratory at an university hospital. Subjects: Twenty one (n = 21) adult sheep of either gender weighing 26.8+/-6.4 kg. Interventions: The animals were randomised to three groups: PFC aerosol (perfluorooctane), PFC group; prostacyclin aerosol (Flolan), PGI2 group; and NaCl aerosol (0.9% sodium chloride solution), control group. After induction of anaesthesia and placement of vascular catheters, lung injury was induced with 0.12 ml x kg(-1) oleic acid. Aerosols were continuously administered for 2 h using a jet nebuliser. Gas exchange, pulmonary mechanic, and haemodynamic parameters were obtained at regular intervals. Measurements and main results: PFC aerosol increased oxygenation (PaO2) 15 min after the initiation of treatment up to 120 min (P < 0.05). Transpulmonary shunt improved in the PFC group (P < 0.05) while it did not change in the two other groups. PFC aerosol reduced maximum airway pressure (Pmax) (median) significantly from (median) 38 mbar to 32 mbar (P < 0.05). Static compliance improved significantly in the PFC group (P < 0.05). Conclusion: The inhalation of a PFC aerosol led to a significant improvement in pulmonary mechanics and gas exchange, which was not observed in the other two groups. These data suggest that a small dose of perfluorocarbon will have beneficial effects on gas exchange and respiratory mechanics. Therefore, the non-invasive aerosol application technique seems to be a reasonable alternative to administer perfluorocarbons in severe lung injury.

Acute lung injury

Aerosol

Jet nebuliser

Low surface tension

Oleic acid

Perfluorocarbons

Prostacyclin

Surfactant

Details

Title: Subtitle: Effects of inhalation of perfluorocarbon aerosol on oxygenation and pulmonary function compared to PGI2 inhalation in a sheep model of oleic acid-induced lung injury
Creators: M. Ragaller - University Hospital Carl Gustav Carus
J. Bleyl - Technische Universität Dresden
U. Tschö - Technische Universität Dresden
T. Winkler - Technische Universität Dresden
M. Regner - Technische Universität Dresden
S. Rasche - Technische Universität Dresden
T. Koch - Technische Universität Dresden
M. Albrecht - Technische Universität Dresden
Resource Type: Journal article
Publication Details: Intensive care medicine, Vol.27(5), pp.889-897
DOI: 10.1007/s001340100921
PMID: 11430546
NLM abbreviation: Intensive Care Med
ISSN: 0342-4642
eISSN: 1432-1238
Publisher: SPRINGER
Number of pages: 9
Language: English
Date published: 05/2001
Academic Unit: Radiology; Anesthesia
Record Identifier: 9985142446202771

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