Journal article
From episodic assessment to comprehensive assessment: integrating real-world monitoring in relapsed/refractory multiple myeloma
Expert review of hematology
05/30/2026
DOI: 10.1080/17474086.2026.2681764
PMID: 42201805
Abstract
Patients with relapsed/refractory multiple myeloma (RRMM) now receive sequential lines of therapy over many years, generating cumulative toxicities, functional decline, and symptom burden that conventional trial endpoints and episodic clinic-based monitoring fail to capture. A synthesis of contemporary real-world monitoring strategies in RRMM is therefore needed to guide clinical practice.
This review examines real-world monitoring strategies for RRMM, encompassing patient-reported outcome (PRO) instruments, real-world data (RWD) sources (electronic health records, claims, registries, patient-driven platforms), and digital health technologies enabling continuous between-visit assessment. Literature was identified through structured searches of PubMed and MEDLINE from January 2000 through April 2026, supplemented by manual review of reference lists and abstracts from major hematology meetings. We evaluate how these strategies complement conventional disease assessment, inform treatment sequencing in the era of CAR T-cell therapies and bispecific antibodies, and address equity gaps in monitoring access.
Integrating PROs, RWD, and digital health tools into routine RRMM care is a necessary evolution toward continuous, personalized disease management; coordinated investment in interoperable data infrastructure, rigorous real-world evidence frameworks, and equity-conscious implementation will be essential to translate these strategies into improved survival and quality of life for all patients.
Details
- Title: Subtitle
- From episodic assessment to comprehensive assessment: integrating real-world monitoring in relapsed/refractory multiple myeloma
- Creators
- Carmel Awadallah - St. Luke's Episcopal HospitalShebli Atrash - Wake Forest UniversityBarry Paul - Wake Forest UniversityAbdullah Mohammad Khan - The Ohio State UniversityHira Shaikh - University of IowaChristopher Strouse - University of IowaZena Chahine - University of KentuckyAnita Mazloom - University of South AlabamaMuhammad Salman Faisal - University of Oklahoma Health Sciences CenterTaha Al-Juhaishi - University of Oklahoma Health Sciences CenterOmar Alkharabsheh - University of CincinnatiPrerna Mewawalla - Alleghany County SchoolsZahra Mahmoudjafari - University of Kansas Medical CenterMuhammad Umair Mushtaq - University of Kansas Medical CenterJeries Kort - University of Kansas Medical CenterAlma Habib - University of Kansas Medical CenterJoseph McGuirk - University of Kansas Medical CenterMansi R Shah - Rutgers, The State University of New JerseySarah Waheed - Johns Hopkins UniversityMahmoud AlJurf - King Faisal Specialist Hospital & Research CentreGhazi Alotaibi - King Saud UniversityAl-Ola Abdallah - University of Kansas Medical Center
- Resource Type
- Journal article
- Publication Details
- Expert review of hematology
- DOI
- 10.1080/17474086.2026.2681764
- PMID
- 42201805
- ISSN
- 1747-4094
- eISSN
- 1747-4094
- Publisher
- Taylor & Francis
- Language
- English
- Electronic publication date
- 05/30/2026
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9985166965702771
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