Journal article
Genetic evaluation of living kidney donor candidates: A review and recommendations for best practices
American journal of transplantation, Vol.23(5), pp.597-607
05/2023
DOI: 10.1016/j.ajt.2023.02.020
PMID: 36868514
Abstract
The increasing accessibility and falling costs of genetic sequencing techniques has expanded the utilization of genetic testing in clinical practice. In living kidney donation, genetic evaluation has been increasingly used to identify genetic kidney disease in potential candidates, especially those of younger age. However, genetic testing on asymptomatic living kidney donors remains fraught with many challenges and uncertainties. Not all transplant practitioners are aware of the limitations of genetic testing, are comfortable with selecting testing methods, comprehending test results, or providing counsel, and many do not have access to a renal genetic counselor or a clinical geneticist. While genetic testing can be a valuable tool in living kidney donor evaluation, its overall benefit in donor evaluation has not been demonstrated and it can also lead to confusion, inappropriate donor exclusion or misleading reassurance. Until more published data is available, this practice resource should provide guidance for centers and transplant practitioners on responsible use of genetic testing in the evaluation of living kidney donor candidates.
Details
- Title: Subtitle
- Genetic evaluation of living kidney donor candidates: A review and recommendations for best practices
- Creators
- Christie P Thomas - Department of of Internal Medicine and Iowa Institute of Human Genetics, University of Iowa Carver College of Medicine, Iowa City, IAReem Daloul - Allegheny General HospitalKrista L Lentine - Saint Louis University HospitalReginald Gohh - Brown UniversityPrince M Anand - University of South Carolina LancasterHila Milo Rasouly - Columbia UniversityAsif A Sharfuddin - Indiana UniversityJohannes Schlondorff - The Ohio State University Wexner Medical CenterNancy Rodig - Boston Children's HospitalMargaret E Freese - University of IowaNeetika Garg - University of Wisconsin School of Medicine and Public HealthBrian K Lee - Seton Medical CenterYasar Caliskan - Saint Louis University Hospital
- Resource Type
- Journal article
- Publication Details
- American journal of transplantation, Vol.23(5), pp.597-607
- DOI
- 10.1016/j.ajt.2023.02.020
- PMID
- 36868514
- NLM abbreviation
- Am J Transplant
- ISSN
- 1600-6135
- eISSN
- 1600-6143
- Publisher
- Elsevier Inc
- Language
- English
- Electronic publication date
- 03/01/2023
- Date published
- 05/2023
- Academic Unit
- Stead Family Department of Pediatrics; Obstetrics and Gynecology; Nephrology; Internal Medicine
- Record Identifier
- 9984375451502771
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