Journal article
Genetic mapping near the myd locus on mouse chromosome 8
Mammalian genome, Vol.6(4), pp.278-280
04/1995
DOI: 10.1007/BF00352416
PMID: 7613034
Abstract
Myodystrophy (myd), an autosomal recessive mutation of the mouse characterized by progressive weakness and dystrophic muscle histology, maps to the central portion of Chromosome (Chr) 8 (Lane et al. J. Hered 67, 135, 1976). This portion of Chr 8 contains the genes for a mitochondrial uncoupling protein (Ucp) and kallikrein (Kal3), which map to distal 4q in the human, providing evidence for a segment of homology. Characteristics of the myd phenotype coupled with this homology suggest that myd may be a mouse homolog of facioscapulohumeral muscular dystrophy (FSHD), which maps to human 4q35. We have confirmed and expanded the region of mouse 8-human 4 homology by generating a map of Chr 8 in an interspecific backcross of C57BL/6J and a partially inbred strain derived from M. spretus. The map is comprised of the genes for Ucp, coagulation factor XI (Cfl1), and chloride channel 5 (Clc5), all of which have homologs on distal human 4q, 15 microsatellite loci, and the membrane cofactor protein pseudogene (Mcp-ps). To place myd in the genetic map, 75 affected progeny from an intersubspecific backcross of animals heterozygous for myd with Mus musculus castaneus were genotyped with Chr 8 microsatellite loci. The mutation maps between D8Mit30 and D8Mit75, an interval that is flanked by genes with human homologs at distal 4q. These results are consistent with the possibility that myd is the mouse homolog of FSHD.
Details
- Title: Subtitle
- Genetic mapping near the myd locus on mouse chromosome 8
- Creators
- K A Mills - Department of Pediatrics, University of Iowa, Iowa City 52242, USAK D MathewsT Scherpbier-HeddemaR L SchelperR SchmalzelH L BaileyJ H NadeauK H BuetowJ C Murray
- Resource Type
- Journal article
- Publication Details
- Mammalian genome, Vol.6(4), pp.278-280
- DOI
- 10.1007/BF00352416
- PMID
- 7613034
- NLM abbreviation
- Mamm Genome
- ISSN
- 0938-8990
- eISSN
- 1432-1777
- Publisher
- United States
- Grant note
- K08 NS 01591-01A1 / NINDS NIH HHS HG00189 / NHGRI NIH HHS 1 P30 HD27748 / NICHD NIH HHS
- Language
- English
- Date published
- 04/1995
- Academic Unit
- Neurology; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Pediatric Dentistry; Craniofacial Anomalies Research Center; Neurology (Pediatrics); Dental Research
- Record Identifier
- 9984020652502771
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