Genitourinary health in a population-based cohort of males with Duchenne and Becker Muscular dystrophies

Yong Zhu; Paul A Romitti; Kristin M Caspers Conway; Sunkyung Kim; Ying Zhang; Michele Yang; Katherine D Mathews; Muscular Dystrophy Surveillance, Tracking, and Research Network

doi:10.1002/mus.24486

Back

Genitourinary health in a population-based cohort of males with Duchenne and Becker Muscular dystrophies

Journal article

Peer reviewed

Genitourinary health in a population-based cohort of males with Duchenne and Becker Muscular dystrophies

Yong Zhu, Paul A Romitti, Kristin M Caspers Conway, Sunkyung Kim, Ying Zhang, Michele Yang, Katherine D Mathews and Muscular Dystrophy Surveillance, Tracking, and Research Network

Muscle & nerve, Vol.52(1), pp.22-27

07/2015

DOI: 10.1002/mus.24486

PMCID: PMC4412791

PMID: 25297835

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/4412791View

Open Access

Abstract

Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data. Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early- vs. late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids). Among the 918 males, 81 (9%) had a GU condition, with voiding dysfunction (n = 40), GU tract infection (n = 19), and kidney/ureter calculus (n = 9) most frequently seen. The Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR 2.7, 95% CI 1.3-5.6). Our findings highlight the need for increased awareness of GU health and multidisciplinary care of DBMD patients.

Humans

Kaplan-Meier Estimate

Child, Preschool

Hospitalization - statistics & numerical data

Male

Risk

Muscular Dystrophy, Duchenne - epidemiology

Muscular Dystrophy, Duchenne - complications

Incidence

Young Adult

Male Urogenital Diseases - etiology

Adolescent

Male Urogenital Diseases - therapy

Adult

Child

Population Surveillance

Cohort Studies

Male Urogenital Diseases - epidemiology

Details

Title: Subtitle: Genitourinary health in a population-based cohort of males with Duchenne and Becker Muscular dystrophies
Creators: Yong Zhu - Department of Epidemiology, The University of Iowa, S416 CPHB, 145 North Riverside Drive, Iowa City, Iowa, 52242, USA
Paul A Romitti - Department of Epidemiology, The University of Iowa, S416 CPHB, 145 North Riverside Drive, Iowa City, Iowa, 52242, USA
Kristin M Caspers Conway - Department of Epidemiology, The University of Iowa, S416 CPHB, 145 North Riverside Drive, Iowa City, Iowa, 52242, USA
Sunkyung Kim - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Ying Zhang - Department of Biostatistics, Indiana University, Indianapolis, Indiana, USA
Michele Yang - Department of Pediatrics, Children's Hospital Colorado, Aurora, Colorado, USA
Katherine D Mathews - Department of Pediatrics, The University of Iowa, Iowa City, Iowa, USA
Muscular Dystrophy Surveillance, Tracking, and Research Network
Resource Type: Journal article
Publication Details: Muscle & nerve, Vol.52(1), pp.22-27
DOI: 10.1002/mus.24486
PMID: 25297835
PMCID: PMC4412791
NLM abbreviation: Muscle Nerve
ISSN: 1097-4598
eISSN: 1097-4598
Publisher: United States
Grant note: U01 DD001119 / NCBDD CDC HHS CC999999 / Intramural CDC HHS U01 DD000831 / NCBDD CDC HHS UL1 TR001108 / NCATS NIH HHS UL1 TR002529 / NCATS NIH HHS
Language: English
Date published: 07/2015
Academic Unit: Neurology; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Biostatistics; Neurology (Pediatrics)
Record Identifier: 9983996064202771

Metrics

13 Record Views

5 Times Cited - Web of Science