Journal article
Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors
Case reports in medicine, Vol.2018, pp.1-4
01/01/2018
DOI: 10.1155/2018/2573657
PMCID: PMC6151688
PMID: 30275836
Abstract
Haploidentical stem cell transplantation provides a plausible alternative for the patients when a fully matched donor is unavailable. Historically, the decision of considering haploidentical transplant has remained elusive; however, with the recent advances, the consideration of haploidentical grafts as a treatment option has become more apparent for both allografting for diseases and engraftment failure. We are reporting here an anecdotal case of a successful haploidentical engraftment in a patient with the prior graft failure of an HLA-matched related donor. Since the patient was severely alloimmunized, desensitization protocol was utilized before the haploidentical transplant, and the patient after 8 months of her second allogeneic transplantation is doing great with successful engraftment, no relapse, and no graft-versus-host disease (GVHD). Numerous reports pertinent to haploidentical graft have shown favorable outcomes in the graft placement, a decline in the rate of GVHD, and an improvement in the morbidity and mortality in affected individuals. Based on the current reports, haploidentical transplantation might be more feasible and has meaningful implications in the situations where matched donors are infrequent.
Details
- Title: Subtitle
- Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors
- Creators
- Hafiz Muhammad Aslam - Seton Hall UniversityShumaila Muhammad Iqbal - Department of Internal Medicine, University at Buffalo (Catholic Health System-Sisters of Charity) Program, Buffalo, USAHira Shaikh - Allegheny Health NetworkFaizan A. Faizee - Dow University of Health SciencesAmbreen A. Merchant - Dow University of Health SciencesMarwan Shaheen - King Faisal Specialist Hospital & Research CentreShahrukh K. Hashmi - Mayo Clinic in Arizona
- Resource Type
- Journal article
- Publication Details
- Case reports in medicine, Vol.2018, pp.1-4
- DOI
- 10.1155/2018/2573657
- PMID
- 30275836
- PMCID
- PMC6151688
- ISSN
- 1687-9627
- eISSN
- 1687-9635
- Language
- English
- Date published
- 01/01/2018
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695685802771
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