Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy

Anmi Jose; Gautham G. Shenoy; Gabriel Sunil Rodrigues; Naveena A. N. Kumar; Murali Munisamy; Levin Thomas; Jill Kolesar; Ganesha Rai; Praveen P. N. Rao; Mahadev Rao

doi:10.3390/cancers12082121

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Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy

Journal article

Open access

Peer reviewed

Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy

Anmi Jose, Gautham G. Shenoy, Gabriel Sunil Rodrigues, Naveena A. N. Kumar, Murali Munisamy, Levin Thomas, Jill Kolesar, Ganesha Rai, Praveen P. N. Rao and Mahadev Rao

Cancers, Vol.12(8), 2121

08/01/2020

DOI: 10.3390/cancers12082121

PMCID: PMC7465382

PMID: 32751840

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Abstract

Lysine-specific demethylase 5B (KDM5B/PLU1/JARID1B) is found to be overexpressed in numerous malignancies, including breast, lung, skin, liver, and prostate cancer. Identification of molecules targeting the KDM5B enzyme could be a potential lead in cancer research. Although many KDM5B inhibitors with promising outcomes have been developed so far, its further application in clinical practice is limited due to toxicity and lack of target specificity. Here, we summarize the significance of targeting KDM5B in anticancer therapy and report the molecular docking studies of some known anti-viral agents, decitabine, entecavir, abacavir, penciclovir, and 3-deazaneplanocin A in the catalytic domain JmjC of KDM5B. These studies show the repurposing potential of identified anti-viral agents in cancer therapy.

Oncology

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy
Creators: Anmi Jose - Manipal Academy of Higher Education
Gautham G. Shenoy - Manipal Academy of Higher Education
Gabriel Sunil Rodrigues - Manipal Acad Higher Educ, Kasturba Med Coll, Dept Surg, Manipal 576104, Karnataka, India
Naveena A. N. Kumar - Manipal Academy of Higher Education
Murali Munisamy - Manipal Academy of Higher Education
Levin Thomas - Manipal Academy of Higher Education
Jill Kolesar - Dept Pharm Practice & Sci, 567 TODD Bldg,789 South Limestone St, Lexington, KY 40539 USA
Ganesha Rai - National Center for Advancing Translational Sciences
Praveen P. N. Rao - University of Waterloo
Mahadev Rao - Manipal Academy of Higher Education
Resource Type: Journal article
Publication Details: Cancers, Vol.12(8), 2121
Publisher: Mdpi
DOI: 10.3390/cancers12082121
PMID: 32751840
PMCID: PMC7465382
ISSN: 2072-6694
eISSN: 2072-6694
Number of pages: 16
Grant note: Manipal Academy of Higher Education, Manipal, India
Language: English
Date published: 08/01/2020
Academic Unit: Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984695787302771

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