Journal article
Hypothyroidism in Head and Neck Squamous Cell Carcinoma Patients Receiving Radiotherapy With or Without Immune Checkpoint Inhibitors
The Laryngoscope, Vol.131(7), pp.E2413-E2419
07/01/2021
DOI: 10.1002/lary.29451
PMID: 33609046
Abstract
Objectives/Hypothesis Hypothyroidism is a relatively common complication of head and neck squamous cell carcinoma (HNSCC) treatment. The objective of this study was to determine whether the addition of programmed death ligand-1 (PD-1) or programmed death ligand-1 (PD-L1) inhibition (anti-PD-1/PD-L1 therapy) to standard treatment increases the risk of hypothyroidism in HNSCC.
Study Design Retrospective Cohort.
Methods This is a retrospective, single institutional cohort study. Patients who received radiotherapy (RT) for HNSCC were identified in the electronic medical record. Patient factors collected include age, sex, body mass index (BMI), smoking status, alcohol use, Charlson comorbidity index, and HNSCC treatment records. The rate of hypothyroidism for patients with HNSCC receiving RT (+/- chemotherapy and surgery) (RT group, n = 101) was compared to that of HNSCC patients receiving RT (+/- chemotherapy and surgery) + anti-PD-1/PD-L1 therapy, either concurrently or after RT (RT + anti-PD-1/PD-L1 group, n = 38).
Results There was no significant difference in the rate of clinical or subclinical hypothyroidism between the two groups. Multinomial logistic regression found no significant difference in hypothyroidism based on age, sex, or BMI.
Conclusions The addition of anti-PD-1/PD-L1 therapy to standard HNSCC treatment does not significantly increase the risk of developing hypothyroidism.
Level of Evidence 3 Laryngoscope, 2021
Details
- Title: Subtitle
- Hypothyroidism in Head and Neck Squamous Cell Carcinoma Patients Receiving Radiotherapy With or Without Immune Checkpoint Inhibitors
- Creators
- Jennifer L. Leddon - University of CincinnatiMartina Chirra - University of CincinnatiAndrew J. Frankart - University of CincinnatiArushi Agrawal - University of CincinnatiLogan Roof - University of CincinnatiDanny Trotier - University of CincinnatiHira Shaikh - University of CincinnatiTimothy Stone - University of CincinnatiRoman Jandarov - University of CincinnatiVinita Takiar - University of CincinnatiTrisha M. Wise-Draper - University of Cincinnati
- Resource Type
- Journal article
- Publication Details
- The Laryngoscope, Vol.131(7), pp.E2413-E2419
- Publisher
- Wiley
- DOI
- 10.1002/lary.29451
- PMID
- 33609046
- ISSN
- 0023-852X
- eISSN
- 1531-4995
- Number of pages
- 7
- Grant note
- Pfizer Eisai; Eisai Co Ltd Caris Life Sciences EpicentRX Bristol-Myers Squibb Merk Tesaro Astrazeneca/MedImmune; AstraZeneca 2UL1TR001425-05A / University of Cincinnati NIH Clinical and Translational Science Award (CTSA program) Lilly; Eli Lilly bexion Boehringer Ingelheim
- Language
- English
- Date published
- 07/01/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695685402771
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