IMPACT OF VENTILATION FREQUENCY AND PARENCHYMAL STIFFNESS ON FLOW AND PRESSURE DISTRIBUTION IN A CANINE LUNG MODEL

Reza Amini; David W Kaczka

doi:10.1007/s10439-013-0866-7

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IMPACT OF VENTILATION FREQUENCY AND PARENCHYMAL STIFFNESS ON FLOW AND PRESSURE DISTRIBUTION IN A CANINE LUNG MODEL

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IMPACT OF VENTILATION FREQUENCY AND PARENCHYMAL STIFFNESS ON FLOW AND PRESSURE DISTRIBUTION IN A CANINE LUNG MODEL

Reza Amini and David W Kaczka

Annals of biomedical engineering, Vol.41(12), pp.2699-2711

12/2013

DOI: 10.1007/s10439-013-0866-7

PMCID: PMC4038105

PMID: 23872936

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https://www.ncbi.nlm.nih.gov/pmc/articles/4038105View

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Abstract

To determine the impact of ventilation frequency, lung volume, and parenchymal stiffness on ventilation distribution, we developed an anatomically-based computational model of the canine lung. Each lobe of the model consists of an asymmetric branching airway network subtended by terminal, viscoelastic acinar units. The model allows for empiric dependencies of airway segment dimensions and parenchymal stiffness on transpulmonary pressure. We simulated the effects of lung volume and parenchymal recoil on global lung impedance and ventilation distribution from 0.1 to 100 Hz, with mean transpulmonary pressures from 5 to 25 cmH 2 O. With increasing lung volume, the distribution of acinar flows narrowed and became more synchronous for frequencies below resonance. At higher frequencies, large variations in acinar flow were observed. Maximum acinar flow occurred at first antiresonance frequency, where lung impedance achieved a local maximum. The distribution of acinar pressures became very heterogeneous and amplified relative to tracheal pressure at the resonant frequency. These data demonstrate the important interaction between frequency and lung tissue stiffness on the distribution of acinar flows and pressures. These simulations provide useful information for the optimization of frequency, lung volume, and mean airway pressure during conventional ventilation or high frequency oscillation (HFOV). Moreover our model indicates that an optimal HFOV bandwidth exists between the resonant and antiresonant frequencies, for which interregional gas mixing is maximized.

Lung volume

computational model

impedance

ventilation distribution

high frequency oscillatory ventilation

mechanical ventilation

Details

Title: Subtitle: IMPACT OF VENTILATION FREQUENCY AND PARENCHYMAL STIFFNESS ON FLOW AND PRESSURE DISTRIBUTION IN A CANINE LUNG MODEL
Creators: Reza Amini - Harvard Medical School, Boston, Massachusetts, United States
David W Kaczka - Harvard Medical School, Boston, Massachusetts, United States
Resource Type: Journal article
Publication Details: Annals of biomedical engineering, Vol.41(12), pp.2699-2711
DOI: 10.1007/s10439-013-0866-7
PMID: 23872936
PMCID: PMC4038105
NLM abbreviation: Ann Biomed Eng
ISSN: 0090-6964
eISSN: 1573-9686
Language: English
Date published: 12/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Anesthesia
Record Identifier: 9984006478402771

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