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Imaging the Injured Lung: Mechanisms of Action and Clinical Use
Journal article   Open access   Peer reviewed

Imaging the Injured Lung: Mechanisms of Action and Clinical Use

Maurizio Cereda, Yi Xin, Alberto Goffi, Jacob Herrmann, David W Kaczka, Brian P Kavanagh, Gaetano Perchiazzi, Takeshi Yoshida and Rahim R Rizi
Anesthesiology (Philadelphia), Vol.131(3), pp.716-749
09/2019
DOI: 10.1097/ALN.0000000000002583
PMID: 30664057
url
https://doi.org/10.1097/ALN.0000000000002583View
Published (Version of record) Open Access

Abstract

The Acute Respiratory Distress Syndrome (ARDS) consists of acute hypoxemic respiratory failure characterized by massive and heterogeneously distributed loss of lung aeration caused by diffuse inflammation and edema present in interstitial and alveolar spaces. It is defined by consensus criteria which include diffuse infiltrates on chest imaging - either plain radiography or computed tomography (CT). In this review we will summarize how imaging sciences can inform modern respiratory management of ARDS and continue to increase our understanding of the acutely injured lung. We describe also newer imaging methodologies that are likely to inform future clinical decision-making and potentially improve outcome. For each imaging modality we systematically describe the underlying principles, the technology involved, measurements obtained, insights gained by the technique, emerging approaches, limitations and future developments. Finally, we consider integrated approaches whereby multimodal imaging may impact on management of ARDS.

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