Journal article
Impact of Mobility Device Use on Quality of Life in Children With Friedreich Ataxia
Journal of child neurology, Vol.33(6), pp.397-404
05/2018
DOI: 10.1177/0883073818764941
PMID: 29607705
Abstract
To determine how mobility device use impacts quality of life in children with Friedreich ataxia.
Data from 111 pediatric patients with genetically confirmed Friedreich ataxia were collected from a prospective natural history study utilizing standardized clinical evaluations, including health-related quality of life using the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Module.
Mobility device use was associated with worse mean PedsQL total, physical, emotional, social, and academic subscores, after adjusting for gender, age of disease onset, and Friedreich Ataxia Rating Scale score. The magnitude of the difference was greatest for the physical subscore (-19.5 points, 95% CI = -30.00, -8.99, P < .001) and least for the emotional subscore (-10.61 points, 95% CI = -20.21, -1.02, P = .03). Transition to or between mobility devices trended toward worse physical subscore (-16.20 points, 95% CI = -32.07, -0.33, P = .05).
Mobility device use is associated with significant worsening of all domains of quality of life in children with Friedreich ataxia.
Details
- Title: Subtitle
- Impact of Mobility Device Use on Quality of Life in Children With Friedreich Ataxia
- Creators
- Resham Ejaz - 1 Division of Clinical and Metabolic Genetics, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, CanadaShiyi Chen - 2 Clinical Research Services, Child Health Evaluative Sciences/Biostatistics Design & Analysis Unit, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, CanadaCharles J Isaacs - 4 Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USAAmanda Carnevale - 1 Division of Clinical and Metabolic Genetics, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, CanadaJudith Wilson - 5 Cardiomyopathy and Heart Function Program, Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, CanadaKristen George - 5 Cardiomyopathy and Heart Function Program, Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, CanadaMartin B Delatycki - 6 Murdoch Childrens Research Institute, Victorian Clinical Genetics Services, Victoria, AustraliaSusan L Perlman - 7 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USAKatherine D Mathews - 8 Departments of Neurology and Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USAGeorge R Wilmot - 9 Department of Neurology, Emory University, Atlanta, GA, USAJ Chad Hoyle - 10 Department of Neurology, Ohio State University College of Medicine, Columbus, OH, USASub H Subramony - 11 Department of Neurology, University of Florida, College of Medicine, Gainesville, FL, USATheresa Zesiewicz - 12 Department of Neurology, University of South Florida, Tampa, FL, USAJennifer M Farmer - 4 Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USADavid R Lynch - 13 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USAGrace Yoon - 14 Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
- Resource Type
- Journal article
- Publication Details
- Journal of child neurology, Vol.33(6), pp.397-404
- Publisher
- United States
- DOI
- 10.1177/0883073818764941
- PMID
- 29607705
- ISSN
- 0883-0738
- eISSN
- 1708-8283
- Grant note
- name: Friedreich Ataxia Research Alliance (FARA) and the AHEPA Family Charitable Foundation of Canada
- Language
- English
- Date published
- 05/2018
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984070748502771
Metrics
6 Record Views