Individual Canine Airway Response Variability to a Deep Inspiration

Robert H Brown; David W Kaczka; Katherine Fallano; Steve Shapiro; Wayne Mitzner

doi:10.4137/CCRPM.S6531

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Individual Canine Airway Response Variability to a Deep Inspiration

Journal article

Open access

Peer reviewed

Individual Canine Airway Response Variability to a Deep Inspiration

Robert H Brown, David W Kaczka, Katherine Fallano, Steve Shapiro and Wayne Mitzner

Clinical medicine insights. Circulatory, respiratory and pulmonary medicine, Vol.5(2011), pp.7-15

12/01/2011

DOI: 10.4137/CCRPM.S6531

PMCID: PMC3072207

PMID: 21487453

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Abstract

In healthy individuals, a DI can reverse (bronchodilation) or prevent (bronchoprotection) induced airway constriction. For individuals with asthma or COPD, these effects may be attenuated or absent. Previous work showed that the size and duration of a DI affected the subsequent response of the airways. Also, increased airway tone lead to increased airway size variability. The present study examined how a DI affected the temporal variability in individual airway baseline size and after methacholine challenge in dogs using High-Resolution Computed Tomography. Dogs were anesthetized and ventilated, and on 4 separate days, HRCT scans were acquired before and after a DI at baseline and during a continuous intravenous infusion of methacholine (Mch) at 3 dose rates (17, 67, and 200 μg/min). The Coefficient of Variation was used as an index of temporal variability in airway size.

Asthma

airway responsiveness

deep inspiration

Original Research

airway smooth muscle

vagal tone

heterogeneity

Details

Title: Subtitle: Individual Canine Airway Response Variability to a Deep Inspiration
Creators: Robert H Brown - Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland
David W Kaczka - Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA
Katherine Fallano - Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland
Steve Shapiro - Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland
Wayne Mitzner - Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland
Resource Type: Journal article
Publication Details: Clinical medicine insights. Circulatory, respiratory and pulmonary medicine, Vol.5(2011), pp.7-15
Publisher: Libertas Academica
DOI: 10.4137/CCRPM.S6531
PMID: 21487453
PMCID: PMC3072207
ISSN: 1179-5484
eISSN: 1179-5484
Language: English
Date published: 12/01/2011
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Anesthesia
Record Identifier: 9984006481302771

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