Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C–positive organ transplantation

Maria T Story; M. Lee Sanders; Amani A Bashir; Jude M Longo; Stacy L Abel; Sheila C Dollard; Elliot I Grodstein; Christie P Thomas; Daniel A Katz

doi:10.1111/tid.13481

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Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C–positive organ transplantation

Journal article

Peer reviewed

Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C–positive organ transplantation

Maria T Story, M. Lee Sanders, Amani A Bashir, Jude M Longo, Stacy L Abel, Sheila C Dollard, Elliot I Grodstein, Christie P Thomas and Daniel A Katz

Transplant infectious disease, Vol.23(2), pp.e13481-n/a

04/2021

DOI: 10.1111/tid.13481

PMID: 33012057

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Abstract

Kaposi sarcoma (KS) following kidney transplantation can result from recipient reactivation of latent human herpesvirus 8 (HHV‐8) infection or activation of donor‐acquired HHV‐8 infection. Post‐transplant KS typically manifests with cutaneous pathology, but rare cases of renal allograft involvement have been reported. We describe two cases of donor‐derived HHV‐8 infection in two hepatitis C (HCV) viremia‐negative transplant recipients who each received a kidney from a donor with HCV viremia. One recipient did not develop KS while the other presented with acute kidney injury caused by extensive KS infiltration of the renal parenchyma and metastatic disease. This report reviews the literature for cases of KS involving the renal allograft and highlights an unexpected consequence of deliberate HCV‐positive organ transplantation.

hepatitis C viremia‐positive donor

human herpesvirus‐8 transmission

Kaposi sarcoma

kidney transplantation

Public Health Service increased risk donor

Details

Title: Subtitle: Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C–positive organ transplantation
Creators: Maria T Story - University of Iowa
M. Lee Sanders - Iowa City VA Health Care System
Amani A Bashir - University of Iowa
Jude M Longo - University of Iowa
Stacy L Abel - Iowa City VA Health Care System
Sheila C Dollard - Centers for Disease Control and Prevention
Elliot I Grodstein - Hofstra University
Christie P Thomas - Iowa City VA Health Care System
Daniel A Katz - University of Iowa
Resource Type: Journal article
Publication Details: Transplant infectious disease, Vol.23(2), pp.e13481-n/a
DOI: 10.1111/tid.13481
PMID: 33012057
ISSN: 1398-2273
eISSN: 1399-3062
Number of pages: 7
Language: English
Date published: 04/2021
Academic Unit: Physician Assistant Studies; Stead Family Department of Pediatrics; Pathology; Surgery; Obstetrics and Gynecology; Nephrology; Internal Medicine
Record Identifier: 9984185272702771

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