Integrated externally and internally generated task predictions jointly guide cognitive control in prefrontal cortex

Jiefeng Jiang; Anthony D Wagner; Tobias Egner

doi:10.7554/eLife.39497

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Integrated externally and internally generated task predictions jointly guide cognitive control in prefrontal cortex

Journal article

Open access

Peer reviewed

Integrated externally and internally generated task predictions jointly guide cognitive control in prefrontal cortex

Jiefeng Jiang, Anthony D Wagner and Tobias Egner

eLife, Vol.7, e39497

08/16/2018

DOI: 10.7554/eLife.39497

PMCID: PMC6126922

PMID: 30113310

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https://doi.org/10.7554/eLife.39497View

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Abstract

Cognitive control proactively configures information processing to suit expected task demands. Predictions of forthcoming demand can be driven by explicit external cues or be generated internally, based on past experience (cognitive history). However, it is not known whether and how the brain reconciles these two sources of information to guide control. Pairing a probabilistic task-switching paradigm with computational modeling, we found that external and internally generated predictions jointly guide task preparation, with a bias for internal predictions. Using model-based neuroimaging, we then show that the two sources of task prediction are integrated in dorsolateral prefrontal cortex, and jointly inform a representation of the likelihood of a change in task demand, encoded in frontoparietal cortex. Upon task-stimulus onset, dorsomedial prefrontal cortex encoded the need for reactive task-set adjustment. These data reveal how the human brain integrates external cues and cognitive history to prepare for an upcoming task.

Magnetic Resonance Imaging

Neuroimaging

Humans

Male

Somatosensory Cortex - diagnostic imaging

Reaction Time - physiology

Psychomotor Performance - physiology

Somatosensory Cortex - physiology

Brain Mapping

Cognition - physiology

Adult

Female

Photic Stimulation

Prefrontal Cortex - physiology

Prefrontal Cortex - diagnostic imaging

Details

Title: Subtitle: Integrated externally and internally generated task predictions jointly guide cognitive control in prefrontal cortex
Creators: Jiefeng Jiang - Department of Psychology, Stanford University, Stanford, United States
Anthony D Wagner - Neuroscience Program, Stanford University, Stanford, United States
Tobias Egner - Department of Psychology and Neuroscience, Duke University, Durham, United States
Resource Type: Journal article
Publication Details: eLife, Vol.7, e39497
DOI: 10.7554/eLife.39497
PMID: 30113310
PMCID: PMC6126922
NLM abbreviation: Elife
ISSN: 2050-084X
eISSN: 2050-084X
Publisher: England
Grant note: R01 MH097965 / NIMH NIH HHS F32AG056080 / National Institute of Aging F32 AG056080 / NIA NIH HHS R21 AG058111 / NIA NIH HHS
Language: English
Date published: 08/16/2018
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984070257102771

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