Journal article
Integrating Pharmacogenomic Testing Into Paired Germline and Somatic Genomic Testing in Patients with Cancer
Pharmacogenomics, Vol.24(13), pp.731-738
08/01/2023
DOI: 10.2217/pgs-2023-0125
PMID: 37702060
Abstract
Precision medicine has revolutionized clinical care for patients with cancer through the development of targeted therapy, identification of inherited cancer predisposition syndromes and the use of pharmacogenetics to optimize pharmacotherapy for anticancer drugs and supportive care medications. While germline (patient) and somatic (tumor) genomic testing have evolved separately, recent interest in paired germline/somatic testing has led to an increase in integrated genomic testing workflows. However, paired germline/somatic testing has generally lacked the incorporation of germline pharmacogenomics. Integrating pharmacogenomics into paired germline/somatic genomic testing would be an efficient method for increasing access to pharmacogenomic testing. In this perspective, the authors argue for the benefits of implementing a comprehensive approach integrating somatic and germline testing that is inclusive of pharmacogenomics in clinical practice.
Details
- Title: Subtitle
- Integrating Pharmacogenomic Testing Into Paired Germline and Somatic Genomic Testing in Patients with Cancer
- Creators
- Nathan D Seligson - University of FloridaJill M Kolesar - University of KentuckyBenish Alam - University of Michigan–Ann ArborLaura Baker - Nemours Center for Cancer & Blood Disorders, Nemours Children’s Health, Wilmington, DE19803, USAJatinder K Lamba - University of FloridaBrooke L Fridley - Moffitt Cancer CenterAmeen A Salahudeen - University of Illinois at ChicagoDaniel L Hertz - University of Michigan–Ann ArborJ Kevin Hicks - Moffitt Cancer Center
- Resource Type
- Journal article
- Publication Details
- Pharmacogenomics, Vol.24(13), pp.731-738
- DOI
- 10.2217/pgs-2023-0125
- PMID
- 37702060
- ISSN
- 1462-2416
- eISSN
- 1744-8042
- Language
- English
- Date published
- 08/01/2023
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984696555902771
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