Journal article
Interaction of Vitamin D and Corticosteroid Use in Hospitalized COVID-19 Patients: A Potential Explanation for Inconsistent Findings in the Literature
Current pharmaceutical design, Vol.28(21), pp.1695-1702
06/2022
DOI: 10.2174/1381612828666220418132847
PMID: 35440302
Abstract
Vitamin D is an important immune-modulator with anti-inflammatory properties. While this prohormone
has been studied extensively in the prevention and treatment of COVID-19, findings have been inconsistent
regarding its overall benefit in patients hospitalized with COVID-19. Most studies to date have been observational
in nature, not accounting for the use of corticosteroids. Furthermore, the few randomized clinical
trials designed to examine the effect of vitamin D supplementation on COVID-19 outcomes have been relatively
small and thus insufficiently powered to assure a balance of corticosteroid use between study arms. The current
perspective addresses the interaction of vitamin D and corticosteroids as a potential explanation for the divergent
results reported in the literature. Future research on vitamin D and COVID-19 will benefit by considering
this interaction, especially among hospitalized patients requiring oxygen and mechanical ventilation.
Details
- Title: Subtitle
- Interaction of Vitamin D and Corticosteroid Use in Hospitalized COVID-19 Patients: A Potential Explanation for Inconsistent Findings in the Literature
- Creators
- Jimmy T. Efird - Durham VA Health Care SystemEthan J. Anderson - Department of Pharmaceutical Sciences and Experimental Therapeutics, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USACharulata Jindal - Harvard UniversityAyako Suzuki - Duke University
- Resource Type
- Journal article
- Publication Details
- Current pharmaceutical design, Vol.28(21), pp.1695-1702
- DOI
- 10.2174/1381612828666220418132847
- PMID
- 35440302
- ISSN
- 1381-6128
- eISSN
- 1873-4286
- Grant note
- DOI: 10.13039/100000738, name: Veterans Affairs (VA) Clinical Science Research and Development COVID Rapid Response program, award: FY2021 ORD-COVID-19-8900-02
- Language
- English
- Date published
- 06/2022
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology
- Record Identifier
- 9984365899702771
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