Journal article
Isolated testicular recurrence of B cell acute lymphoblastic leukaemia in an adult: rare case
BMJ case reports, Vol.12(10), p.e232286
10/01/2019
DOI: 10.1136/bcr-2019-232286
PMCID: PMC6827919
PMID: 31676503
Abstract
An 80-year-old man who was previously diagnosed with Philadelphia+ B cell-acute lymphoblastic leukaemia (B-ALL) in remission post-allogeneic matched unrelated donor peripheral blood stem cell transplant. Five years later, he was found to have unilateral testicular relapse of Philadelphia+ B-ALL proven by pathology after radical orchiectomy. Bone marrow aspirate and biopsy did not show evidence of leukaemia. Patient was treated with adjuvant radiation therapy and started on dasatinib 50 mg daily. Given his age and absence of disseminated acutelymphoblastic leukaemia (ALL), no adjuvant chemotherapy was utilised. He is monitored with monthly PCR studies. At 1-year follow-up, no findings suggestive of recurrence of ALL have been identified and the patient is maintained on the dasatinib. Although isolated testicular recurrence is common among paediatric population, it is a rare event among adults as it is considered an immunological sanctuary for cancer cells.
Details
- Title: Subtitle
- Isolated testicular recurrence of B cell acute lymphoblastic leukaemia in an adult: rare case
- Creators
- Thejus Jayakrishnan - Allegheny Health NetworkHira Shaikh - Allegheny Health NetworkYazan Samhouri - Allegheny Health NetworkAriel Sandhu - Allegheny Health Network
- Resource Type
- Journal article
- Publication Details
- BMJ case reports, Vol.12(10), p.e232286
- Publisher
- BMJ
- DOI
- 10.1136/bcr-2019-232286
- PMID
- 31676503
- PMCID
- PMC6827919
- ISSN
- 1757-790X
- eISSN
- 1757-790X
- Language
- English
- Date published
- 10/01/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695834302771
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