Learning through a Pandemic: The Current State of Knowledge on COVID-19 and Cancer

Arielle Elkrief; Julie T Wu; Chinmay Jani; Kyle T Enriquez; Michael Glover; Mansi R Shah; Hira Ghazal Shaikh; Alicia Beeghly-Fadiel; Benjamin French; Sachin R Jhawar; Douglas B Johnson; Rana R McKay; Donna R Rivera; Daniel Y Reuben; Surbhi Shah; Stacey L Tinianov; Donald Cuong Vinh; Sanjay Mishra; Jeremy L Warner

doi:10.1158/2159-8290.CD-21-1368

Journal article

Learning through a Pandemic: The Current State of Knowledge on COVID-19 and Cancer

Arielle Elkrief, Julie T Wu, Chinmay Jani, Kyle T Enriquez, Michael Glover, Mansi R Shah, Hira Ghazal Shaikh, Alicia Beeghly-Fadiel, Benjamin French, Sachin R Jhawar, …

Cancer discovery, Vol.12(2), pp.303-330

02/01/2022

DOI: 10.1158/2159-8290.CD-21-1368

PMCID: PMC8831477

PMID: 34893494

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https://www.ncbi.nlm.nih.gov/pmc/articles/8831477View

Open Access

Abstract

The ongoing coronavirus disease 2019 (COVID-19) pandemic has left patients with current or past history of cancer facing disparate consequences at every stage of the cancer trajectory. This comprehensive review offers a landscape analysis of the current state of the literature on COVID-19 and cancer, including the immune response to COVID-19, risk factors for severe disease, and impact of anticancer therapies. We also review the latest data on treatment of COVID-19 and vaccination safety and efficacy in patients with cancer, as well as the impact of the pandemic on cancer care, including the urgent need for rapid evidence generation and real-world study designs. SIGNIFICANCE: Patients with cancer have faced severe consequences at every stage of the cancer journey due to the COVID-19 pandemic. This comprehensive review offers a landscape analysis of the current state of the field regarding COVID-19 and cancer. We cover the immune response, risk factors for severe disease, and implications for vaccination in patients with cancer, as well as the impact of the COVID-19 pandemic on cancer care delivery. Overall, this review provides an in-depth summary of the key issues facing patients with cancer during this unprecedented health crisis.

COVID-19 - complications

COVID-19 - epidemiology

COVID-19 - therapy

Humans

Neoplasms - complications

Neoplasms - immunology

Neoplasms - therapy

Pandemics

Details

Title: Subtitle: Learning through a Pandemic: The Current State of Knowledge on COVID-19 and Cancer
Creators: Arielle Elkrief - McGill University Health Centre
Julie T Wu - Stanford University
Chinmay Jani - Mount Auburn Hospital
Kyle T Enriquez - Vanderbilt University
Michael Glover - Stanford University
Mansi R Shah - Rutgers, The State University of New Jersey
Hira Ghazal Shaikh - University of Cincinnati
Alicia Beeghly-Fadiel - Vanderbilt University Medical Center
Benjamin French - Vanderbilt University Medical Center
Sachin R Jhawar - The Ohio State University
Douglas B Johnson - Vanderbilt University Medical Center
Rana R McKay - University of California San Diego
Donna R Rivera - National Cancer Institute
Daniel Y Reuben - Medical University of South Carolina
Surbhi Shah - Mayo Clinic in Florida
Stacey L Tinianov - Advocates for Youth
Donald Cuong Vinh - McGill University Health Centre
Sanjay Mishra - Vanderbilt University Medical Center
Jeremy L Warner - Vanderbilt University Medical Center
Resource Type: Journal article
Publication Details: Cancer discovery, Vol.12(2), pp.303-330
DOI: 10.1158/2159-8290.CD-21-1368
PMID: 34893494
PMCID: PMC8831477
NLM abbreviation: Cancer Discov
ISSN: 2159-8274
eISSN: 2159-8290
Grant note: P30 CA068485 / NCI NIH HHS
Language: English
Date published: 02/01/2022
Academic Unit: Internal Medicine
Record Identifier: 9984695683102771

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