Light Chain Deposition Disease After Kidney Transplantation With Long Graft Survival: Case Report

S Kuppachi; D Holanda; C P Thomas

doi:10.1016/j.transproceed.2015.12.009

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Light Chain Deposition Disease After Kidney Transplantation With Long Graft Survival: Case Report

Journal article

Peer reviewed

Light Chain Deposition Disease After Kidney Transplantation With Long Graft Survival: Case Report

S Kuppachi, D Holanda and C P Thomas

Transplantation proceedings, Vol.48(1), pp.255-258

01/2016

DOI: 10.1016/j.transproceed.2015.12.009

PMID: 26915878

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Abstract

Light Chain Deposition Disease (LCDD) is a monoclonal immunoglobulin deposition disease that commonly affects kidneys among other organs. It leads to end-stage renal disease and has a high disease recurrence rate after kidney transplantation. This has led some authors to advise against transplantation in view of the poor long-term graft and patient outcomes. Recent literature has shown improvement/stabilization of native kidney disease following the use of bortezomib. We present 2 cases of LCDD after transplantation with graft dysfunction. They were both treated with different therapeutic agents to induce remission. Because sustained remission was not achieved they received bortezomib following which they have experienced a prolonged period of stable renal function with no clinically detectable disease. These unique cases highlight the possibility to achieve long-term stable graft function and disease remission after renal transplantation for LCDD.

Kidney - surgery

Paraproteinemias - drug therapy

Transplants - physiopathology

Humans

Kidney Failure, Chronic - drug therapy

Middle Aged

Graft Survival

Male

Antineoplastic Agents - therapeutic use

Kidney Transplantation

Immunoglobulin Light Chains

Bortezomib - therapeutic use

Kidney Failure, Chronic - complications

Adult

Remission Induction - methods

Paraproteinemias - etiology

Postoperative Complications

Kidney - physiopathology

Details

Title: Subtitle: Light Chain Deposition Disease After Kidney Transplantation With Long Graft Survival: Case Report
Creators: S Kuppachi - Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA. Electronic address: sarat-kuppachi@uiowa.edu
D Holanda - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
C P Thomas - Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA; Department of Internal Medicine, VA Medical Center, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: Transplantation proceedings, Vol.48(1), pp.255-258
Publisher: United States
DOI: 10.1016/j.transproceed.2015.12.009
PMID: 26915878
ISSN: 0041-1345
eISSN: 1873-2623
Language: English
Date published: 01/2016
Academic Unit: Stead Family Department of Pediatrics; Pathology; Obstetrics and Gynecology; Internal Medicine
Record Identifier: 9983985904202771

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