Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35

K D Mathews; K A Mills; E P Bosch; V V Ionasescu; K R Wiles; K H Buetow; J C Murray

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Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35

Journal article

Peer reviewed

Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35

K D Mathews, K A Mills, E P Bosch, V V Ionasescu, K R Wiles, K H Buetow and J C Murray

American journal of human genetics, Vol.51(2), pp.428-431

08/1992

PMCID: PMC1682681

PMID: 1642242

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Abstract

Fasioscapulohumeral muscular dystrophy (FSHD) has recently been localized to 4q35. We have studied four families with FSHD. Linkage to the 4q35 probes D4S163, D4S139, and D4S171 was confirmed. We found no recombinants helpful in detailed localization of the FSHD gene. Two of our families include males with a rapidly progressive muscle disease that had been diagnosed, on the basis of clinical features, as Duchenne muscular dystrophy. One of these males is available for linkage study and shares the haplotype of his FSHD-affected aunt and cousin.

Details

Title: Subtitle: Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35
Creators: K D Mathews - Department of Pediatrics, University of Iowa College of Medicine, Iowa City
K A Mills - Department of Pediatrics, University of Iowa College of Medicine, Iowa City
E P Bosch - Department of Pediatrics, University of Iowa College of Medicine, Iowa City
V V Ionasescu - Department of Pediatrics, University of Iowa College of Medicine, Iowa City
K R Wiles - Department of Pediatrics, University of Iowa College of Medicine, Iowa City
K H Buetow - Department of Pediatrics, University of Iowa College of Medicine, Iowa City
J C Murray - Department of Pediatrics, University of Iowa College of Medicine, Iowa City
Resource Type: Journal article
Publication Details: American journal of human genetics, Vol.51(2), pp.428-431
PMID: 1642242
PMCID: PMC1682681
NLM abbreviation: Am J Hum Genet
ISSN: 0002-9297
eISSN: 1537-6605
Language: English
Date published: 08/1992
Academic Unit: Neurology; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Pediatric Dentistry; Craniofacial Anomalies Research Center; Neurology (Pediatrics); Dental Research
Record Identifier: 9984020706702771

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