Journal article
Liquid biopsy approaches for pleural effusion in lung cancer patients
Molecular biology reports, Vol.47(10), pp.8179-8187
10/01/2020
DOI: 10.1007/s11033-020-05869-7
PMID: 33029702
Abstract
Genomic profiling of tumors has become the mainstay for diagnosis, treatment monitoring and a guide to precision medicine. However, in clinical practice, the detection of driver mutations in tumors has several procedural limitations owing to progressive disease and tumor heterogeneity. The current era of liquid biopsy promises a better solution. This diagnostic utility of liquid biopsy has been demonstrated by numerous studies for the detection of cell-free DNA (cfDNA) in plasma for disease diagnosis, prognosis, and prediction. However, cfDNAs are limited in blood circulation and still hurdles to achieve promising precision medicine. Malignant pleural effusion (MPE) is usually detected in advanced lung malignancy, which is rich in tumor cells. Extracellular vesicles and cfDNAs are the two major targets currently explored using MPE. Therefore, MPE can be used as a source of biomarkers in liquid biopsy for investigating tumor mutations. This review focuses on the liquid biopsy approaches for pleural effusion which may be explored as an alternative source for liquid biopsy in lung cancer patients to diagnose early disease progression.
Details
- Title: Subtitle
- Liquid biopsy approaches for pleural effusion in lung cancer patients
- Creators
- Gayathri Baburaj - Manipal Academy of Higher EducationRama Rao Damerla - Manipal Academy of Higher EducationKarthik S. Udupa - Manipal Academy of Higher EducationPreetiparna Parida - Kasturba Medical College, ManipalMurali Munisamy - Manipal Academy of Higher EducationJill Kolesar - University of KentuckyMahadev Rao - Manipal Academy of Higher Education
- Resource Type
- Journal article
- Publication Details
- Molecular biology reports, Vol.47(10), pp.8179-8187
- Publisher
- Springer Nature
- DOI
- 10.1007/s11033-020-05869-7
- PMID
- 33029702
- ISSN
- 0301-4851
- eISSN
- 1573-4978
- Number of pages
- 9
- Grant note
- DST/INSPIRE Fellowship/2018/IF180737 / DST-INSPIRE Fellowship, Department of Science and Technology, Government of India, New Delhi, India
- Language
- English
- Date published
- 10/01/2020
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984695791802771
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