Journal article
Lung [ F-18] fluorodeoxyglucose Uptake and Ventilation-Perfusion Mismatch in the Early Stage of Experimental Acute Smoke Inhalation
Anesthesiology (Philadelphia), Vol.120(3), pp.683-693
03/2014
DOI: 10.1097/01.anes.0000435742.04859.e8
PMCID: PMC4129461
PMID: 24051392
Abstract
Background: Acute lung injury occurs in a third of patients with smoke inhalation injury. Its clinical manifestations usually do not appear until 48-72 h after inhalation. Identifying inflammatory changes that occur in pulmonary parenchyma earlier than that could provide insight into the pathogenesis of smoke-induced acute lung injury. Furthermore, noninvasive measurement of such changes might lead to earlier diagnosis and treatment. Because glucose is the main source of energy for pulmonary inflammatory cells, the authors hypothesized that its pulmonary metabolism is increased shortly after smoke inhalation, when classic manifestations of acute lung injury are not yet expected.
Methods: In five sheep, the authors induced unilateral injury with 48 breaths of cotton smoke while the contralateral lung served as control. The authors used positron emission tomography with: (1) [F-18]fluorodeoxyglucose to measure metabolic activity of pulmonary inflammatory cells; and (2) [N-13]nitrogen in saline to measure shunt and ventilation-perfusion distributions separately in the smoke-exposed and control lungs.
Results: The pulmonary [F-18]fluorodeoxyglucose uptake rate was increased at 4 h after smoke inhalation (mean SD: 0.0031 +/- 0.0013 vs. 0.0026 +/- 0.0010 min(-1); P < 0.05) mainly as a result of increased glucose phosphorylation. At this stage, there was no worsening in lung aeration or shunt. However, there was a shift of perfusion toward units with lower ventilation-to-perfusion ratio (mean ratio +/- SD: 0.82 +/- 0.10 vs. 1.12 +/- 0.02; P < 0.05) and increased heterogeneity of the ventilation-perfusion distribution (mean +/- SD: 0.21 +/- 0.07 vs. 0.13 +/- 0.01; P < 0 .05).
Conclusion: Using noninvasive imaging, the authors demonstrated that increased pulmonary [F-18]fluorodeoxyglucose uptake and ventilation-perfusion mismatch occur early after smoke inhalation.
Details
- Title: Subtitle
- Lung [ F-18] fluorodeoxyglucose Uptake and Ventilation-Perfusion Mismatch in the Early Stage of Experimental Acute Smoke Inhalation
- Creators
- Guido Musch - Massachusetts General HospitalTilo Winkler - Massachusetts General HospitalR. Scott Harris - Massachusetts General HospitalMarcos F. Vidal Melo - Massachusetts General HospitalTyler J. Wellman - Massachusetts General HospitalNicolas de Prost - Massachusetts General HospitalRichard L. Kradin - Massachusetts General HospitalJose G. Venegas - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- Anesthesiology (Philadelphia), Vol.120(3), pp.683-693
- DOI
- 10.1097/01.anes.0000435742.04859.e8
- PMID
- 24051392
- PMCID
- PMC4129461
- NLM abbreviation
- Anesthesiology
- ISSN
- 0003-3022
- eISSN
- 1528-1175
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 11
- Grant note
- 8895 / Shriners Hospitals for Children, Boston, Massachusetts R01HL094639 / National Institutes of Health Grant, Bethesda, Maryland R01HL094639 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 03/2014
- Academic Unit
- Anesthesia
- Record Identifier
- 9985142951302771
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