Journal article
Macrophage Repolarization as a Therapeutic Strategy for Osteosarcoma
International journal of molecular sciences, Vol.24(3), 2858
02/02/2023
DOI: 10.3390/ijms24032858
PMCID: PMC9917837
PMID: 36769180
Abstract
Macrophages are versatile immune cells and can adapt to both external stimuli and their surrounding environment. Macrophages are categorized into two major categories; M1 macrophages release pro-inflammatory cytokines and produce protective responses that lead to antimicrobial or antitumor activity. M2 or tumor-associated macrophages (TAM) release anti-inflammatory cytokines that support tumor growth, invasion capacity, and metastatic potential. Since macrophages can be re-polarized from an M2 to an M1 phenotype with a variety of strategies, this has emerged as an innovative anti-cancer approach. Osteosarcoma (OS) is a kind of bone cancer and consists of a complex niche, and immunotherapy is not very effective. Therefore, immediate attention to new strategies is required. We incorporated the recent studies that have used M2-M1 repolarization strategies in the aspect of treating OS cancer.
Details
- Title: Subtitle
- Macrophage Repolarization as a Therapeutic Strategy for Osteosarcoma
- Creators
- Namrata Anand - University of KentuckyKeng Hee Peh - University of KentuckyJill M Kolesar - University of Kentucky
- Resource Type
- Journal article
- Publication Details
- International journal of molecular sciences, Vol.24(3), 2858
- DOI
- 10.3390/ijms24032858
- PMID
- 36769180
- PMCID
- PMC9917837
- ISSN
- 1661-6596
- eISSN
- 1422-0067
- Grant note
- PON2 728 2000002500 / Kentucky Cabinet For Health and Family Services
- Language
- English
- Date published
- 02/02/2023
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984695787802771
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