Journal article
Mathematical modeling of ventilation defects in asthma
Drug discovery today. Disease models, Vol.15, pp.3-8
2015
DOI: 10.1016/j.ddmod.2014.02.008
PMID: 26744595
Abstract
Airway narrowing by smooth muscle constriction is a hallmark of asthma attacks that may cause severe difficulties of breathing. However, the causes of asthma and the underlying mechanisms are not fully understood. Bronchoconstriction within a bronchial tree involves complex interactions among the airways that lead to the emergence of regions of poor ventilation (ventilation defects, VDefs) in the lungs. The emphasis of this review is on mathematical modeling of the mechanisms involved in bronchoconstriction and the emergence of the complex airway behavior that leads to VDefs. Additionally, the review discusses characteristic model behaviors and experimental data to demonstrate advances and limitations of different models.
Details
- Title: Subtitle
- Mathematical modeling of ventilation defects in asthma
- Creators
- Tilo Winkler - Massachusetts General HospitalJose G. Venegas - Harvard UniversityR. Scott Harris - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- Drug discovery today. Disease models, Vol.15, pp.3-8
- DOI
- 10.1016/j.ddmod.2014.02.008
- PMID
- 26744595
- NLM abbreviation
- Drug Discov Today Dis Models
- ISSN
- 1740-6757
- eISSN
- 1740-6757
- Publisher
- Elsevier Ltd
- Number of pages
- 6
- Language
- English
- Date published
- 2015
- Academic Unit
- Anesthesia
- Record Identifier
- 9985142947902771
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