Minimal Change Disease With Nephrotic Syndrome Associated With Coronavirus Disease 2019 After Apolipoprotein L1 Risk Variant Kidney Transplant: A Case Report

Masaaki Yamada; Prerna Rastogi; Dilek Ince; Abdullah Thayyil; M Adela Mansilla; Richard J.H Smith; Sarat Kuppachi; Christie P Thomas

doi:10.1016/j.transproceed.2020.08.012

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Minimal Change Disease With Nephrotic Syndrome Associated With Coronavirus Disease 2019 After Apolipoprotein L1 Risk Variant Kidney Transplant: A Case Report

Journal article

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Minimal Change Disease With Nephrotic Syndrome Associated With Coronavirus Disease 2019 After Apolipoprotein L1 Risk Variant Kidney Transplant: A Case Report

Masaaki Yamada, Prerna Rastogi, Dilek Ince, Abdullah Thayyil, M Adela Mansilla, Richard J.H Smith, Sarat Kuppachi and Christie P Thomas

Transplantation proceedings, Vol.52(9), pp.2693-2697

11/2020

DOI: 10.1016/j.transproceed.2020.08.012

PMCID: PMC7440148

PMID: 32972761

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Abstract

Kidney injury is a well-known complication in people with coronavirus disease 2019 (COVID-19). In kidney transplant recipients with COVID-19, presentation with nephrotic syndrome has not been well described. We report on a 49-year-old black female kidney transplant recipient who presented 25 years after transplant with clinical features of nephrotic syndrome following a diagnosis of COVID-19. Histologic examination showed acute tubular injury with unremarkable glomeruli on light microscopy and diffuse foot process effacement of podocytes on electron microscopy, consistent with minimal change–like podocyte injury. Apolipoprotein L1 (APOL1) genetic testing confirmed 2 high-risk APOL1 alleles in the kidney donor. We speculate that COVID-19–induced systemic or local cytokine release could serve as a second hit in the presence of APOL1 risk alleles and mediate a podocytopathy manifesting as nephrotic syndrome. The presented case with minimal change–like disease, occurring in the context of the donor high-risk APOL1 genotype, extends the spectrum of clinical manifestations in COVID-19–associated nephropathy. •Kidney injury is common in coronavirus disease 2019 (COVID-19).•Minimal change disease can be seen as COVID-19–associated nephropathy.•High-risk apolipoprotein L1 may contribute to development of COVID-19–associated nephropathy.

Details

Title: Subtitle: Minimal Change Disease With Nephrotic Syndrome Associated With Coronavirus Disease 2019 After Apolipoprotein L1 Risk Variant Kidney Transplant: A Case Report
Creators: Masaaki Yamada - University of Iowa
Prerna Rastogi - University of Iowa
Dilek Ince - University of Iowa
Abdullah Thayyil - East Carolina University
M Adela Mansilla - University of Iowa
Richard J.H Smith - University of Iowa
Sarat Kuppachi - University of Iowa
Christie P Thomas - University of Iowa
Resource Type: Journal article
Publication Details: Transplantation proceedings, Vol.52(9), pp.2693-2697
DOI: 10.1016/j.transproceed.2020.08.012
PMID: 32972761
PMCID: PMC7440148
NLM abbreviation: Transplant Proc
ISSN: 0041-1345
eISSN: 1873-2623
Publisher: Elsevier Inc
Language: English
Date published: 11/2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Infectious Diseases; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Obstetrics and Gynecology; Nephrology; Otolaryngology; Internal Medicine; Iowa Institute of Human Genetics
Record Identifier: 9984186522202771

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