Journal article
Modeling of Tracer Transport Delays for Improved Quantification of Regional Pulmonary F-FDG Kinetics, Vascular Transit Times, and Perfusion
Annals of biomedical engineering, Vol.43(11), pp.2722-2734
11/01/2015
DOI: 10.1007/s10439-015-1327-2
PMCID: PMC4618094
PMID: 25940652
Abstract
18F-FDG-PET is increasingly used to assess pulmonary inflammatory cell activity. However, current models of pulmonary 18F-FDG kinetics do not account for delays in 18F-FDG transport between the plasma sampling site and the lungs. We developed a three-compartment model of 18F-FDG kinetics that includes a delay between the right heart and the local capillary blood pool, and used this model to estimate regional pulmonary perfusion. We acquired dynamic 18F-FDG scans in 12 mechanically ventilated sheep divided into control and lung injury groups (n = 6 each). The model was fit to tracer kinetics in three isogravitational regions-of-interest to estimate regional lung transport delays and regional perfusion. 13NN bolus infusion scans were acquired during a period of apnea to measure regional perfusion using an established reference method. The delayed input function model improved description of 18F-FDG kinetics (lower Akaike Information Criterion) in 98% of studied regions. Local transport delays ranged from 2.0 to 13.6 s, averaging 6.4 ± 2.9 s, and were highest in non-dependent regions. Estimates of regional perfusion derived from model parameters were highly correlated with perfusion measurements based on 13NN-PET (R 2 = 0.92, p < 0.001). By incorporating local vascular transports delays, this model of pulmonary 18F-FDG kinetics allows for simultaneous assessment of regional lung perfusion, transit times, and inflammation.
Details
- Title: Subtitle
- Modeling of Tracer Transport Delays for Improved Quantification of Regional Pulmonary F-FDG Kinetics, Vascular Transit Times, and Perfusion
- Creators
- Tyler J. Wellman - Massachusetts General HospitalTilo Winkler - Massachusetts General HospitalMarcos F. Vidal Melo - Harvard Medical School
- Resource Type
- Journal article
- Publication Details
- Annals of biomedical engineering, Vol.43(11), pp.2722-2734
- DOI
- 10.1007/s10439-015-1327-2
- PMID
- 25940652
- PMCID
- PMC4618094
- NLM abbreviation
- Ann Biomed Eng
- ISSN
- 0090-6964
- eISSN
- 1573-9686
- Publisher
- SPRINGER
- Grant note
- R01HL086827 / National Heart, Lung, and Blood Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000050) R01-HL121228 / National Heart, Lung, and Blood Institute R01-HL086827; R01-HL121228 / National Heart, Lung, and Blood Institute R01-HL086827 / National Heart, Lung, and Blood Institute
- Language
- English
- Date published
- 11/01/2015
- Academic Unit
- Anesthesia
- Record Identifier
- 9985141864402771
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