Modeling pulmonary kinetics of 2-deoxy-2-[F-18]fluoro-D-glucose during acute lung injury

Tobias Schroeder; Marcos F. Vidal Melo; Guido Musch; R. Scott Harris; Jose G. Venegas; Tilo Winkler

doi:10.1016/j.acra.2007.12.016

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Modeling pulmonary kinetics of 2-deoxy-2-[F-18]fluoro-D-glucose during acute lung injury

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Modeling pulmonary kinetics of 2-deoxy-2-[F-18]fluoro-D-glucose during acute lung injury

Tobias Schroeder, Marcos F. Vidal Melo, Guido Musch, R. Scott Harris, Jose G. Venegas and Tilo Winkler

Academic radiology, Vol.15(6), pp.763-775

06/01/2008

DOI: 10.1016/j.acra.2007.12.016

PMCID: PMC2474713

PMID: 18486012

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https://www.ncbi.nlm.nih.gov/pmc/articles/2474713View

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Abstract

Rationale and Objectives. Dynamic positron emission tomographic imaging of the radiotracer 2-deoxy-2-[F-18]fluoro-D-glucose (F-18-FDG) is increasingly used to assess metabolic activity of lung inflammatory cells. To analyze the kinetics of F-18-FDG in brain and tumor tissues, the Sokoloff model has been typically used. In the lungs, however, a high blood-to-parenchymal volume ratio and F-18-FDG distribution in edematous injured tissue could require a modified model to properly describe F-18-FDG kinetics. Materials and Methods. We developed and validated a new model of lung F-18-FDG kinetics that includes an extravascular/noncellular compartment in addition to blood and F-18-FDG precursor pools for phosphorylation. Parameters obtained from this model were compared with those obtained using the Sokoloff model. We analyzed dynamic PET data from 15 sheep with smoke or ventilator-induced lung injury. Results. In the majority of injured lungs, the new model provided better fit to the data. than the Sokoloff model. Rate of pulmonary F-18-FDG net uptake and distribution volume in the precursor pool for phosphorylation correlated between the two models (R-2 = 0.98, 0.78), but were overestimated with the Sokoloff model by 17% (P <.05) and 16% (P <.0005) compared to the new one. The range of the extravascular/noncellular F-18-FDG distribution Volumes was up to 13% and 49% of lung tissue volume in smoke- and ventilator-induced lung injury, respectively. Conclusion. The lung-specific model predicted F-18-FDG kinetics during acute lung injury more accurately than the Sokoloff model and may provide new insights in the pathophysiology of lung injury.

Life Sciences & Biomedicine

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Details

Title: Subtitle: Modeling pulmonary kinetics of 2-deoxy-2-[F-18]fluoro-D-glucose during acute lung injury
Creators: Tobias Schroeder - Massachusetts General Hospital
Marcos F. Vidal Melo - Massachusetts General Hospital
Guido Musch - Harvard University
R. Scott Harris - Gen Digital Inc. (United States)
Jose G. Venegas - Harvard University
Tilo Winkler - Harvard University
Resource Type: Journal article
Publication Details: Academic radiology, Vol.15(6), pp.763-775
DOI: 10.1016/j.acra.2007.12.016
PMID: 18486012
PMCID: PMC2474713
NLM abbreviation: Acad Radiol
ISSN: 1076-6332
eISSN: 1878-4046
Publisher: Elsevier
Number of pages: 13
Grant note: HL-056879; R01-HL-086827; R01 HL086827-02; R01 HL086827; R01 HL068011; K08 HL076464-03; HL-068011; R01 HL068011-05A2; HL-076464; K08 HL076464 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) K08HL076464 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
Language: English
Date published: 06/01/2008
Academic Unit: Anesthesia
Record Identifier: 9985142950602771

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