Journal article
Modularity in the genetic disease-phenotype network
FEBS letters, Vol.582(17), pp.2549-2554
07/23/2008
DOI: 10.1016/j.febslet.2008.06.023
PMID: 18582463
Abstract
Similar disease phenotypes are engendered as a result of the modular nature of gene networks; thus we hypothesized that all human genetic disease phenotypes appear in similar modular styles. Network representations of phenotypes make it possible to explore this hypothesis. We investigated the modularity of a network of genetic disease phenotypes. We computationally extracted phenotype modules and found that the modularity is well correlated with a physiological classification of human diseases. We also found correlations between the modularity and functional genomics as well as its connection to drug-target associations.
Details
- Title: Subtitle
- Modularity in the genetic disease-phenotype network
- Creators
- Xingpeng JiangBing LiuJiefeng Jiang - University of Iowa, Iowa Neuroscience InstituteHuizhi ZhaoMing FanJing ZhangZhenjie FanTianzi Jiang
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.582(17), pp.2549-2554
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.febslet.2008.06.023
- PMID
- 18582463
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Language
- English
- Date published
- 07/23/2008
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984095781002771
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