Neuroprotective Mechanisms of the ACE2-Angiotensin-(1-7)-Mas Axis in Stroke

Douglas M. Bennion; Emily Haltigan; Robert W. Regenhardt; U. Muscha Steckelings; Colin Sumners

doi:10.1007/s11906-014-0512-2

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Neuroprotective Mechanisms of the ACE2-Angiotensin-(1-7)-Mas Axis in Stroke

Journal article

Peer reviewed

Neuroprotective Mechanisms of the ACE2-Angiotensin-(1-7)-Mas Axis in Stroke

Douglas M. Bennion, Emily Haltigan, Robert W. Regenhardt, U. Muscha Steckelings and Colin Sumners

Current hypertension reports, Vol.17(2), pp.3-3

02/01/2015

DOI: 10.1007/s11906-014-0512-2

PMCID: PMC4378688

PMID: 25620630

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https://www.ncbi.nlm.nih.gov/pmc/articles/4378688View

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Abstract

The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that describe the protective role of the ACE2Ang-(1-7)-Mas axis in stroke, along with a focused discussion on the potential mechanisms of neuroprotective effects of Ang-(1-7) in stroke. The latter incorporates evidence describing the actions of Ang-(1-7) to counter the deleterious effects of angiotensin II (AngII) via its type 1 receptor, including antiinflammatory, anti-oxidant, vasodilatory, and angiogenic effects, and the role of altered kinase-phosphatase signaling. Interactions of Mas with other receptors, including bradykinin receptors and AngII type 2 receptors are also considered. A more complete understanding of the mechanisms of action of Ang-(1-7) to elicit neuroprotection will serve as an essential step toward research into potential targeted therapeutics in the clinical setting.

Cardiovascular System & Cardiology

Life Sciences & Biomedicine

Peripheral Vascular Disease

Science & Technology

Details

Title: Subtitle: Neuroprotective Mechanisms of the ACE2-Angiotensin-(1-7)-Mas Axis in Stroke
Creators: Douglas M. Bennion - University of Florida
Emily Haltigan - University of Florida
Robert W. Regenhardt - University of Florida
U. Muscha Steckelings - University of Southern Denmark
Colin Sumners - University of Florida
Resource Type: Journal article
Publication Details: Current hypertension reports, Vol.17(2), pp.3-3
DOI: 10.1007/s11906-014-0512-2
PMID: 25620630
PMCID: PMC4378688
NLM abbreviation: Curr Hypertens Rep
ISSN: 1522-6417
eISSN: 1534-3111
Publisher: Springer Nature
Number of pages: 10
Grant note: McKnight Brain Institute HL076803; 2T32HL083810-06A1 / National Heart, Lung and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 12PRE11940010 / American Heart Association Greater Southeast Affiliate; American Heart Association
Language: English
Date published: 02/01/2015
Academic Unit: Otolaryngology
Record Identifier: 9984962531502771

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