Journal article
Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome
Current opinion in physiology, Vol.21, pp.36-43
06/01/2021
DOI: 10.1016/j.cophys.2021.03.006
PMCID: PMC8056876
PMID: 33898903
Abstract
For patients with the acute respiratory distress syndrome (ARDS), ventilation strategies that limit end-expiratory derecruitment and end-inspiratory overdistension are the only interventions to have significantly reduced the morbidity and mortality. For this reason, the use of high-frequency oscillatory ventilation (HFOV) was considered to be an ideal protective strategy, given its reliance on very low tidal volumes cycled at very high rates. However, results from clinical trials in adults with ARDS have demonstrated that HFOV does not improve clinical outcomes. Recent experimental and computational studies have shown that oscillation of a mechanically heterogeneous lung with multiple simultaneous frequencies can reduce parenchymal strain, improve gas exchange, and maintain lung recruitment at lower distending pressures compared to traditional 'single-frequency' HFOV. This review will discuss the theoretical rationale for the use of multiple oscillatory frequencies in ARDS, as well as the mechanisms by which it may reduce the risk for ventilator-induced lung injury.
Details
- Title: Subtitle
- Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome
- Creators
- David W. Kaczka - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Current opinion in physiology, Vol.21, pp.36-43
- Publisher
- Elsevier
- DOI
- 10.1016/j.cophys.2021.03.006
- PMID
- 33898903
- PMCID
- PMC8056876
- ISSN
- 2468-8673
- eISSN
- 2468-8673
- Number of pages
- 8
- Grant note
- R41 HL140640 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Department of Anesthesia at the University of Iowa Hospital and Clinics
- Language
- English
- Date published
- 06/01/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Anesthesia
- Record Identifier
- 9984295958002771
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